Intraductal Sebaceous Papilloma of a Meibomian Gland: A New Entity Possibly Associated with the MSH6 Subtype of the Muir-Torre Syndrome

Over several months a 63 year old man developed a painless, multinodular, non-erythematous swelling of the deep tissues of his left upper eyelid. An excisional biopsy with histopathologic evaluation disclosed a unique sebaceous papilloma within a cyst lined by non-keratinizing squamous epithelium that focally displayed a variably thick, superficial, eosinophilic cuticular layer. Immunohistochemical staining demonstrated that the tumor and its epithelial cystic lining had a profile consistent with Meibomian gland duct epithelium.

Source: Survey of Ophthalmology - September 22, 2019 Category: Opthalmology Authors: Frederick A. Jakobiec, Paula Cortes Barrantes, Daniel R. Lefebvre, Tatyana Milman Tags: Major review Source Type: research