Direct evaluation of peripheral airways using ultra-high-resolution CT in chronic obstructive pulmonary disease

Publication date: Available online 20 September 2019Source: European Journal of RadiologyAuthor(s): Naoya Tanabe, Hiroshi Shima, Susumu Sato, Tsuyoshi Oguma, Takeshi Kubo, Satoshi Kozawa, Koji Koizumi, Atsuyasu Sato, Kaori Togashi, Toyohiro HiraiAbstractPurposeDisease in small airways
Source: European Journal of Radiology - Category: Radiology Source Type: research

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We examined whether CT-derived lung volumes representing air trapping could predict adverse respiratory outcomes and more rapid decline in spirometry to overt COPD using mixed-effect linear modelling. Among these subjects with normal forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio, CT-measured residual volume (RVCT) to total lung capacity (TLCCT) ratio varied widely, from 21% to 59%. Over 2.5±0.7 years of follow-up, subjects with higher RVCT/TLCCT had a greater differential rate of decline in FEV1/FVC; those in the upper RVCT/TLCCT tertile had a 0.66% (95% CI 0.06%–1.27%) ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: COPD Source Type: research
We describe a 66‐year‐old man with severe chronic obstructive pulmonary disease (COPD) who faile d assessments for BLVR because of the inability to perform the carbon monoxide diffusion test but subsequently had EBV deployed to his right upper lobe bronchi for persistent air leak complicating a spontaneous pneumothorax. Afterwards, there was subjective improvement in breathlessness, exercise ca pacity, and reduced frequency of exacerbations requiring hospitalization. Lung function parameters showed marked improvement. This case suggests that patients with compatible spirometric lung volume and computed tomography findi...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
The objective of this review is to summarize the major advances in the clinical epidemiology of COPD from the first 10 years of the COPDGene study. We highlight the influence of age, gender, and race on the natural history of COPD, and the impact of comorbid conditions, chronic bronchitis, exacerbations, and asthma - COPD overlap (ACO). PMID: 31154041 [PubMed - as supplied by publisher]
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
294Objectives: HIV infection dramatically increases TB risk. Antiretroviral therapy (ART) improves survival in HIV-infected adults with pulmonary TB but ART-mediated functional immune restoration may trigger the TB immune reconstitution inflammatory syndrome (TB-IRIS). No studies to our knowledge have evaluated the relationship between ART initiation, immune recovery, local lung inflammation, and longer term lung function in HIV/TB. We decided to use FDG PET-CT to test the hypothesis that robust ART-mediated immune recovery induces pulmonary inflammation and impairs lung function in HIV/TB co-infected adults. Methods: The ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Outcomes/Infectious Disease/Pulmonary II Source Type: research
Abstract Special attention has emerged towards biomass smoke-induced chronic obstructive pulmonary disease (COPD), providing new knowledge for prevention and therapeutic approach of non-smoker COPD patients. However, the understanding of biomass smoke COPD is still limited and somewhat controversial. The aim of the present study was to compare COPD exclusively caused by tobacco smoking with COPD exclusively caused by environmental or occupational exposures. For this cross-sectional study, COPD patients were recruited from outpatient clinics and formed two groups: non-smoker COPD group (n=16) with exposure to bioma...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
This study investigated whether DISH is associated with restrictive spirometry pattern (RSP) in former and current smokers. METHODS: 1,784 participants with complete post-bronchodilator spirometry who did not meet spirometric criteria for COPD at time of enrollment in the COPDGene study were included in this study. Subjects were classified as RSP if they had Forced Expiratory volume in one second \(FEV1) to Forced Vital Capacity (FVC) ratio> 0.7 with an FVC
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
ConclusionA voxel-wise longitudinal PRM analytic approach can identify patterns of disease progression in smokers with and without chronic obstructive pulmonary disease.
Source: Academic Radiology - Category: Radiology Source Type: research
Background: The extent to which genetic risk of COPD is mediated by variation in lung structure remains unknown.Aims: To determine whether a recently developed genetic risk score for lung function (GRS; Wain LV et al, Nat Genet 2017; 49(3):416-425) is associated with CT lung structure.Methods: In SPIROMICS, a cohort of COPD subjects and at-risk smokers (≥20 pack-years), a weighted GRS was calculated from 83 of 95 single nucleotide polymorphisms genotyped or imputed across 3 race/ethnic groups. Post-bronchodilator spirometry and CT scan measures (via Apollo/VIDA) of lung density, spatially-matched airway dimensions, and ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Genes and environment Source Type: research
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Introduction: Patients with COPD may present with different clinical characteristics and response to treatment which has led to increased efforts to identify those who share similar characteristics. The overlap between COPD and bronchiectasis has been established as a unique phenotype as patients are prone to more severe and frequent exacerbations. Aims:to compare clinical and functional features of patients diagnosed with COPD and bronchiectasis to those who had COPD.Methods: A retrospective study, 70 patients diagnosed with COPD (based on spirometry tests) followed at our department (2014-2017). All patients had a chest ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
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