Endometriosis and ectopic pregnancy: A meta-analysis

Publication date: Available online 20 September 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Paul J. Yong, Samaa Matwani, Chantalle Brace, Andrea Quaiattini, Mohamed A. Bedaiwy, Arianne Albert, Catherine AllaireAbstractObjectiveTo systematically review and perform a meta-analysis of the risk of ectopic pregnancy in endometriosis.Data sourcesMEDLINE (OVID), Embase (OVID), CINAHL (EBSCO) and Cochrane to April 1, 2019. Inclusion criteria: cohort or case-control studies from 1990 onwards. Exclusion criteria: cohort studies without controls, case reports or series, or no English full-text.Methods of study selection1361 titles/abstracts were screened after removal of duplicates, 39 full-texts were requested, and after 14 studies were excluded, there were 15 studies in the meta-analysis.Tabulation, Integration, and ResultsData was extracted utilizing standardized spreadsheets with two independent reviewers, and conflicts broken by a third reviewer. We performed random effects calculation of weighted estimated average Odds Ratios (OR). Heterogeneity and publication bias were assessed with the I2 metric and funnel plots/Egger's test, respectively. The Ottawa-Newcastle quality assessment scale was utilized with a cut-off of ≥ 7 for higher quality. There were ten case-control studies (17,972 ectopic pregnancy cases and 485,266 non-ectopic pregnancy controls), and five cohort studies (30,609 women with endometriosis and 107,321 women without endometriosis). For case-...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research

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ovich P, Murber Á, Bokor A Abstract Introduction: Bowel endometriosis is when endometrial-like tissue penetrates the bowel serosa, or it reaches the subserous neurovascular plexus. The effect of surgery for colorectal endometriosis on infertility and pregnancy is not fully proven. Aim: The aim of the present study was to analyse the pregnancy outcome and mode of delivery of patients who underwent 'nerve sparing' anterior resection of the colon. Method: Between 2009 and 2017, we operated 121 patients with bowel endometriosis, and built up a prospective database where we assessed their wish of pregnancy, the ...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research
In conclusion, MALAT1 reduction was identified in GCs, which may contribute to the pathophysiological processes of PCOS by regulating TGFβ signaling through sponging miR-125b and miR-203a.
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
ConclusionsInfertile women with stage I and II endometriosis present systemic oxidative stress during the early follicular phase of the menstrual cycle. Some oxidative stress markers were good predictors of clinical pregnancy and live births after ICSI. Serum TAC was predictive of clinical pregnancy and live births after ICSI in women with stage I or II endometriosis.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionInfertile women with 2 or more IVF-ICSI failures may be referred for surgery as it appears related to good postoperative pregnancy rates, particularly when endometriomas surgery is either not required or not performed. Surgery for DIE does not routinely delay conception, as it usually occurs during the year following surgery.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Abstract Stanniocalcin-1 (STC-1) is a pro-survival factor that protects tissues against stressors, such as hypoxia and inflammation. STC-1 is co-expressed with the endometrial receptivity markers, and recently endometrial STC-1 was reported to be dysregulated in endometriosis, a condition linked with endometrial progesterone resistance and inflammation. These features are also common in the endometrium in women with polycystic ovary syndrome (PCOS), the most common endocrine disorder in women. Given that women with PCOS present with subfertility, pregnancy complications, and increased risk for endometrial cancer, ...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
Some things you might like to know about.StatisticsMaternity statisticsApril 2019May 2019 Quarterly conceptions to women aged under 18 years (England)April to June 2018Public Health EnglandGeneration genome and the opportunities for screening programmesIncludes opportunities in screening for fetal anomalies, sickle cell and thalassemia, infectiosu diseases in pregnancy, and newborn blood spot screening and newborn hearing screening.NewsLots this time...The man who gave birth (Guardian podcast)Freddy McConnell is a trans man who decided to begin the process of conceiving and delivering his own child.  The fil...
Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
Authors: Naeh A, Bruchim I, Hallak M, Gabbay-Benziv R PMID: 31474021 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
This study presents the postoperative pregnancy rate of women with recurrent endometriosis and evaluates the predictive value of the endometriosis fertility index (EFI) for the pregnancy. A total of 107 women who wished to conceive after surgery for recurrent endometriosis from January 2007 to December 2016 were included. The EFI score was calculated postoperatively. The receiver operator characteristic (ROC) curve was plotted to determine the most promising contributor to predicting pregnancy, and Kaplan–Meier (K–M) analysis was used to estimate the cumulative pregnancy rate (CPR). A total of 61 pregnancies ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Patients face a problem in IVF/ICSI treatment,repeated planting failure.In order to explore whether endometriosis affects the implantation of embryo when IVF/ICSI,this study compared the pregnancy outcomes of patients with endometriosis who failed to implant repeatedly.So as to explore the appropriate treatment plan for such patients.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
It is widely accepted that angiogenesis is pivotal to the establishment of endometriotic lesions and it is fundamental in the regulation of placental development starting from the early stages of pregnancy. Circulating vascular endothelial growth factor and placental growth factor (PLGF) levels have been reported to be increased in women with endometriosis when compared with controls, conversely decreased levels of PLFG have been reported in pregnant women developing preeclampsia. For this reason, the presence of endometriosis might be a protective factor for the development of early onset preeclampsia during pregnancy, si...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
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