Ascl2-Regulated Follicular Helper T Cells Promote Autoimmunity in a Murine Model for Sj ögren’s Syndrome

Follicular helper T (Tfh) cells contribute to various immune responses as well as to the pathogenesis of several immune diseases. However, the precise mechanism underlying the onset or development of autoimmunity via Tfh cells remains unclear. Here, the detailed relationship between autoimmune disease and Tfh cells was analyzed using a murine model for Sj ögren’s syndrome (SS) wherein the mice underwent neonatal thymectomy. Germinal center (GC) development was promoted in this SS model along with an increase of Tfh cells and GC B cells.

Source: American Journal of Pathology - September 16, 2019 Category: Pathology Authors: Kunihiro Otsuka, Akiko Yamada, Masako Saito, Aya Ushio, Mami Sato, Satoru Kisoda, Wenhua Shao, Takaaki Tsunematsu, Yasusei Kudo, Rieko Arakaki, Naozumi Ishimaru Tags: Regular Article Source Type: research