Regioselective strategies for the synthesis of Group Ia and Ib Streptococcus related glycans enable elucidating unique conformations of the capsular polysaccharides.

We described development of efficient regioselective routes for GlcNAcβ1-3[Glcβ1-4)]Gal synthons giving access to different GBS Ia and Ib repeating unit frameshifts. These glycans were used to probe the conformation and molecular dynamics of the two polysaccharides, highlighting the different presentation of the protruding Neu5Acα2-3Gal moieties on the polysaccharide backbones and a higher flexibility of Ib polymer compared to Ia which can impact epitope exposure.
PMID: 31506992 [PubMed - as supplied by publisher]

Source: Chemistry - September 9, 2019 Category: Chemistry Authors: Del Bino L, Calloni I, Oldrini D, Raso MM, Cuffaro R, Arda A, Codée J, Jiménez-Barbero J, Adamo R Tags: Chemistry Source Type: research