hyaluronate (hyaluronan, Hyalgan, Supartz, Euflexxa, Orthovisc)

Title: hyaluronate (hyaluronan, Hyalgan, Supartz, Euflexxa, Orthovisc)Category: MedicationsCreated: 3/2/2005 12:00:00 AMLast Editorial Review: 9/4/2019 12:00:00 AM
Source: MedicineNet Arthritis General - Category: Rheumatology Source Type: news

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This article summarizes the milestones in the development of upadacitinib leading to this first approval for the treatment of rheumatoid arthritis.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins. VPAC receptors seem to preferentially interact with Gs in inflammatory cells, rather than Gq, thereby stimulating adenylate cyclase activity. cAMP is able to trigger various downstream pathways, mainly the canonical PKA pathway and the non-canonical cAMP-activated guanine nucleotide exchange factor (EPAC) pathway. Classically, the presence of VPACs has been confined to the plasma membrane; however, VPAC1 location has been described in the ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Regulated hemostasis, inflammation and innate immunity entail extensive interactions between platelets and neutrophils. Under physiological conditions, vascular inflammation offers a template for the establishment of effective intravascular immunity, with platelets providing neutrophils with an array of signals that increase their activation threshold, thus limiting collateral damage to tissues and promoting termination of the inflammatory response. By contrast, persistent systemic inflammation as observed in immune-mediated diseases, such as systemic vasculitides, systemic sclerosis, systemic lupus erythematosus or rheuma...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The latest crowdfunded research project undertaken by the SENS Research Foundation involves using the genetically engineered maximally modifiable mouse lineage in order to demonstrate the ability to copy a version of the ATP8 mitochondrial gene into the cell nucleus, a process known as allotopic expression, and thus prevent mutational damage to this gene from degrading mitochondrial function. This is a modest step on the road towards bringing this class of genetic engineering project to the point of readiness for commercial development, when a biotech startup company could be created to carry it forward. In just a f...
Source: Fight Aging! - Category: Research Authors: Tags: Activism, Advocacy and Education Source Type: blogs
Publication date: Available online 20 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Sacco, S. Shah, R. Leeson, V. Moraschini, C.F. de Almeida Barros Mourão, O. Akintola, A. LalliAbstractTumour necrosis factor-α (TNF-α) inhibitors are increasingly being used as immunomodulators to manage inflammatory conditions such as rheumatoid arthritis and Crohn’s disease. Reported serious side effects include an increased incidence of lymphoma and greater susceptibility to infections such as tuberculosis. The aim of this systematic review was to find out whether there is an ...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 21 October 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Yuyan Guo, Shaowa lü, Bingyou Yang, Guoyu Li, Wenbao Ma, Qiaoxin Guo, Qiuhong Wang, Haixue KuangAbstractCaulophyllum robustum Maxim (CRM) is a well-known traditional Chinese medicine (TCM) mainly present in the northeast, northwest and southwest regions of China, which is belong to the family Berberidaceae. The roots and rhizomes of CRM have been used as a famous TCM for the treatment of rheumatoid arthritis (RA). The selective, sensitive and accurate high-performance liquid chromatography-electrospray...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
Condition:   Arthritis, Juvenile Intervention:   Behavioral: Sleep Manipulation Protocol Sponsors:   The Hospital for Sick Children;   Children's Hospital Medical Center, Cincinnati;   Canadian Institutes of Health Research (CIHR) Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Natural News) Don’t let rheumatoid arthritis get you down. There are many natural ways to manage the pain of inflamed joints without resorting to pharmaceutical drugs. Products Start by applying a hot pad or an ice pack to the swollen joint. An ice pack decreases inflammation and swelling during an attack, while a heating pad relaxes...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Contributor : Lo KenSeries Type : Protein profiling by protein arrayOrganism : Homo sapiens8 controls and 26 RA samples were profiled using NimbleTherapeutics high density peptide array. Array consists of>4.6M peptides, includes citrullination and homocitrullination against the entire human proteome represented as overlapping 16mer peptides.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Protein profiling by protein array Homo sapiens Source Type: research
Publication date: Available online 19 October 2019Source: Autoimmunity ReviewsAuthor(s): Andrea Rubbert-Roth, Melinda Zsuzsanna Szabó, Melinda Kedves, György Nagy, Fabiola Atzeni, Piercarlo Sarzi-PuttiniAbstractThe five TNF inhibitors currently approved for the treatment of RA are characterised by differences in their molecular structures, half-lives, administration routes, dosing intervals, immunogenicity, and use in women who wish to become pregnant. TNF inhibitors still represent the first biologic after conventional synthetic DMARD (csDMARD) in the majority of patients according to registry data. This was p...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
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