657 Induction of IL-11 expression leads to persistent abnormal fibroblast activity in cutaneous wound healing

Injury of the skin can provoke excessive accumulation of extracellular matrix (ECM) leading to a hypertrophic scar or keloid development. However, the mechanism responsible for the persistence of the fibrotic response in a wound healing process is yet not well understood. There is growing evidence that abnormal fibroblast activity mediated by IL-11 signalling plays the pivotal role in systemic organ fibrosis. Therefore, we investigated whether the pathologic activity of myofibroblast-like keloid fibroblast (KFs) are potentiated by hypoxia-induced mesenchymal transition mediated by IL-11.

Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: J. Kim, B. Kim, S. Kim, Y. Lee, J. Lee Tags: Wound Healing and Tissue Remodelling Source Type: research