The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

This study therefore maps A20 as a crucial regulator of mTOR signaling and underscores the need for a tightly balanced mTOR pathway in NK cell homeostasis.

Source: The Journal of Experimental Medicine - September 1, 2019 Category: Internal Medicine Authors: Vetters, J., van Helden, M. J., Wahlen, S., Tavernier, S. J., Martens, A., Fayazpour, F., Vergote, K., Vanheerswynghels, M., Deswarte, K., Van Moorleghem, J., De Prijck, S., Takahashi, N., Vandenabeele, P., Boon, L., van Loo, G., Vivier, E., Lambrecht, B. Tags: Innate Immunity and Inflammation Brief Definitive Reports Source Type: research