Oncolytic Viruses Engineered to Enforce Leptin Expression, Reprogram Tumor-Infiltrating T Cell Metabolism, and Promote Tumor Clearance

Metabolic insufficiency is a major barrier for antitumor immunity. Rivadeneira et  al. demonstrate that engineering an oncolytic virus to express a metabolic modulator, in this case the adipokine leptin, improves T cell metabolic function in the tumor microenvironment, allowing a superior antitumor response compared to a control oncolytic.

Source: Immunity - August 26, 2019 Category: Allergy & Immunology Authors: Dayana B. Rivadeneira, Kristin DePeaux, Yiyang Wang, Aditi Kulkarni, Tracy Tabib, Ashley V. Menk, Padmavathi Sampath, Robert Lafyatis, Robert L. Ferris, Saumendra N. Sarkar, Stephen H. Thorne, Greg M. Delgoffe Tags: Article Source Type: research