Newborn Screening for Severe Combined Immunodeficiency

The T-cell receptor excision circle (TREC) assay is an effective screening tool for severe combined immunodeficiency (SCID). The TREC assay was designed to detect typical SCID and leaky SCID, but any condition causing low na ïve T-cell counts will also be detected. Newborn screening for SCID using the TREC assay has proven itself to be highly sensitive and cost-efficient. This review covers the history of SCID newborn screening, elaborates on the SCID subtypes and TREC assay limitations, and discusses diagnostic and ma nagement considerations for infants with a positive screen.

Source: Pediatric Clinics of North America - August 27, 2019 Category: Pediatrics Authors: Mohammed Taki, Tayaba Miah, Elizabeth Secord Source Type: research