Current concepts of cerebrospinal fluid dynamics and the translaminar cribrosa pressure gradient: a paradigm of optic disc disease

Modern advances in measuring and studying cerebrospinal fluid (CSF) dynamics have furthered our understan ding of intracranial pressure (ICP) and its pathophysiological effects on the eye. In particular, the CSF pressure and composition within the optic nerve subarachnoid space (SAS) are key factors in diseases of the optic disc. ICP and intraocular pressure (IOP) establish a pressure gradient across the lamina cribrosa (LC). Alterations in this translaminar cribrosa pressure difference (TLPD) induce structural deformations in the LC manifested clinically by the appearance of optic disc edema (ODE) or optic disc cupping.

Source: Survey of Ophthalmology - August 22, 2019 Category: Opthalmology Authors: Katy C. Liu, David Fleischman, Andrew G. Lee, Hanspeter E. Killer, John J. Chen, M. Tariq Bhatti Tags: Major review Source Type: research