Medical News Today: Inflammation in type 2 diabetes: Study overturns previous notions

New research challenges the prevalent belief that it is glucose that drives chronic inflammation in obesity and obesity-related type 2 diabetes.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Diabetes Type 2 Source Type: news

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Authors: Williams JS, Lu K, Akinboboye O, Olukotun O, Zhou Z, Nagavally S, Egede LE Abstract Objectives: Diabetes results in $327 billion in medical expenditures annually, while obesity, a risk factor for type 2 diabetes, leads to more than $147 billion in expenditure annually. The aims of this study were: 1) to evaluate racial/ethnic trends in obesity and medical expenditures; and 2) to assess incremental medical expenditures among a nationally representative sample of women with diabetes. Methods: Nine years of data (2008-2016) from the Medical Expenditure Panel Survey Full Year Consolidated File (unweighted ...
Source: Ethnicity and Disease - Category: International Medicine & Public Health Tags: Ethn Dis Source Type: research
Conclusions/interpretationIn older adults with type 2 diabetes, long-term adiposity may have a detrimental impact on volume of brain regions relevant to cognitive functioning. Further studies to identify the underlying mechanisms are warranted.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research
AbstractAims/hypothesisThe aim of this study was to use Mendelian randomisation (MR) to identify the causal risk factors for type 2 diabetes.MethodsWe first conducted a review of meta-analyses and review articles to pinpoint possible risk factors for type 2 diabetes. Around 170 possible risk factors were identified of which 97 risk factors with available genetic instrumental variables were included in MR analyses. To reveal more risk factors that were not included in our MR analyses, we conducted a review of published MR studies of type 2 diabetes. For our MR analyses, we used summary-level data from the DIAbetes Genetics ...
Source: Diabetologia - Category: Endocrinology Source Type: research
Conclusion: Our study provides evidence for insulin and lipid regulation of endocrine FGFs in healthy and PCOS women, suggesting that FGF family members play a role in lipid and glucose metabolism.Clinical Trial Registration:www.isrctn.org, Identifier: ISRCTN42448814.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This study tested the association between serum levels of microRNA-486, −146b and -15b and betatrophin in normal and obese children with/without type 2 diabetes mellitus (T2DM).
Source: BMC Endocrine Disorders - Category: Endocrinology Authors: Tags: Research article Source Type: research
TYPE 2 diabetes is linked with being overweight or inactive, so it is possible to put type 2 diabetes into remission. Here's how to reverse type 2 diabetes.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractThe present study sought to determine if episodic future thinking (EFT) can decrease delay discounting (DD) and demand for fast food under simulations of economic scarcity in adults at risk for diabetes (i.e., overweight/obese and with hemoglobin A1c values in, or approaching, the prediabetic range). Across two sessions, participants completed assessments of DD and food demand at baseline and while prompted to: (1) engage in either EFT or control episodic recent thinking, and (2) while reading a brief narrative describing either economic scarcity or neutral income conditions. Results showed that EFT significantly r...
Source: Journal of Behavioral Medicine - Category: Psychiatry Source Type: research
This review summarizes fish protein hydrolysates (FPH) and their effect on blood glucose/obesity. Specific peptides in these FPH are also discussed. The results show that FPH are generally useful for lowering blood glucose and managing appetite. By addressing methodological issues, and if future studies focus on discovering mechanism of action, they could be useful for future nutritional interventions. AbstractPrevalence of type 2 diabetes and overweight/obesity are increasing globally. Food supplementation as a preventative option has become an attractive option in comparison to increased pharmacotherapy dependency. Hydro...
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Review Source Type: research
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Obesity-induced activation and proliferation of resident macrophages and infiltration of circulating monocytes in adipose tissues contribute to adipose tissue inflammation and insulin resistance. These effects further promote the development of metabolic syndromes, such as type 2 diabetes, which is one of the most prevalent health conditions severely threatening human health worldwide. Our study examined the potential molecular mechanism employed by fibroblast growth factor 1 (FGF1) to improve insulin sensitivity. The leptin receptor-deficient obese mice (db/db) served as an insulin-resistant model. Our r...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
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