124. 3D-printed hyperelastic bone ® composite scaffolds as bone graft substitutes

Iliac crest bone graft (ICBG) has long been considered the gold standard implant for use in spinal fusion procedures. Due to significant donor site morbidity associated with graft harvest, however, use of ICBG has largely been abandoned in favor of other materials. Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on an absorbable collagen sponge (ACS; Infuse) is an effective bone graft substitute, but the supra-physiologic doses required to achieve fusion are associated with significant adverse clinical outcomes.

Source: The Spine Journal - August 23, 2019 Category: Orthopaedics Authors: Joseph G. Lyons, Allison Greene, Jonathan T. Yamaguchi, David J. Ellenbogen, Mitchell Hallman, Vivek P. Shah, Tejas Nandurkar, Mark A. Plantz, Chawon Yun, Soyeon Jeong, Ramille N. Shah, Adam E. Jakus, Robert M. Havey, Muturi Muriuki, Avinash G. Patwardhan Source Type: research