124. 3D-printed hyperelastic bone ® composite scaffolds as bone graft substitutes

Iliac crest bone graft (ICBG) has long been considered the gold standard implant for use in spinal fusion procedures. Due to significant donor site morbidity associated with graft harvest, however, use of ICBG has largely been abandoned in favor of other materials. Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on an absorbable collagen sponge (ACS; Infuse) is an effective bone graft substitute, but the supra-physiologic doses required to achieve fusion are associated with significant adverse clinical outcomes.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research

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Publication date: Available online 14 September 2019Source: Journal of Microbiological MethodsAuthor(s): Victoria Stadler Tasca Ribeiro, Letícia Kraft, Paula Hansen Suss, Juliette Cieslinski, Luciana Cristina Wollmann, Felipe Francisco TuonAbstractAlthough reports of infections caused by anaerobes after tissue transplantation are uncommon, contamination of allografts may result in substantial complications. Anaerobic incubation and testing of organ transport solution (TS) are not routine. The aim of this study was to determine the bioburden of strict anaerobic bacteria and oxygen tension of heart-TS. Forty TS from d...
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
Increasing experience with Haplo-HSCT has brought attention to unique toxicities that may be less common with other modalities of transplantation such as cytokine release syndrome (CRS) [1 –3]. We read with interest the study of Dr. Imus et al. [4]. The authors report a large retrospective experience on cytokine release syndrome (CRS) after haplo-HSCT using peripheral blood (PB) allografts and post-transplant cyclophosphamide (PTCy) for graft-versus-host disease (GVHD) prophylaxis [ 4].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Publication date: Available online 12 September 2019Source: Arthroscopy TechniquesAuthor(s): Michael DeFrance, Elizabeth Ford, Sean McMillanAbstractThe critical role of the meniscus in the biomechanics of the knee and articular cartilage preservation has led to an increased awareness of the importance of the meniscus. Meniscal allograft transplantation is a challenging surgical intervention that is saved as a last resort for patients who meet stringent criteria for salvage from meniscal deficiency. Proper arthroscopic implantation of a meniscal allograft takes precision and implementation of multiple fixation techniques to...
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
Publication date: Available online 11 September 2019Source: Arthroscopy TechniquesAuthor(s): Chad Lavender, Brock Johnson, Vishavpreet Singh, Eric Dennis, LeeAnne TorresAbstractThe use of biologics in sports medicine is increasing rapidly. Bone marrow concentrate has recently increased in popularity because it includes mesenchymal stem cells which, combined with AlloSync Pure, could lead to better incorporation and healing. The mixture of bone marrow concentrate and Allosync Pure can be used in anterior cruciate ligament reconstruction. We recently expanded on this approach with the addition of saving the host bone normall...
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
Publication date: Available online 11 September 2019Source: Arthroscopy TechniquesAuthor(s): Kyle N. Kunze, Robert A. Burnett, Kevin K. Shinsako, Charles A. Bush-Joseph, Brian J. Cole, Jorge ChahlaAbstractRevision quadriceps tendon repair presents a challenging problem for the treating surgeon because of associated anatomic defects such as large tendon-gap deficits and preexistent poor tissue quality. Current methods for revision quadriceps tendon repair use tendon autograft, which may predispose to additional morbidity because the repair relies only on soft tissue fixation. In this Technical Note, we describe a technique ...
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
AbstractBackgroundLate acute cellular rejection (LACR) is associated with poorer graft outcomes and non-adherence. Non-adherence to tacrolimus can be indirectly assessed by the intra-patient variability (IPV) of tacrolimus trough levels. The threshold of IPV associated with rejection is not known.MethodsWe conducted a case-control study comparing 25 patients with biopsy-proven LACR against 25 stable controls matched for age group, primary diagnosis and time post-transplant. IPV was calculated using coefficient of variance (CV) and mean absolute deviation (MAD) using tacrolimus levels in the preceding 12  months. We al...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionMRI signal varies with graft type, graft source, and time after ACLR. Enhanced graft maturity during the first postoperative year was associated with hamstring autografts, with and without remnant preservation. Serial MRI imaging during the first postoperative year may be clinically useful to identify biologically or mechanically deficient ACL grafts at risk for failure.Level of evidenceIV
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Large glenoid defects present a challenge during primary and revision reverse total shoulder arthroplasty (RTSA) especially when humeral head autograft is not available as a bone graft source. The purpose of this study was to evaluate the clinical and radiographic outcomes of RTSA with concomitant structural allografting to reconstruct large glenoid defects.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Source Type: research
To compare the risk of anterior cruciate ligament (ACL) revision and the patient-reported outcome after ACL reconstruction with a concomitant non-surgically treated medial collateral ligament (MCL) injury with regard to 3 ACL graft choices; the use of semitendinosus (ST), the use of semitendinosus-gracilis (ST-G), and the use of patellar tendon (PT) autograft. It was hypothesized that the use of ST-G would be associated with a greater risk of ACL revision and poorer patient-reported knee function.
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - Category: Surgery Authors: Source Type: research
To evaluate whether characteristics such as age, height, weight, sex, or body mass index affected the distal tibial dimensions and radius of curvature (ROC) of a potential donor for anterior glenoid augmentation.
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - Category: Surgery Authors: Source Type: research
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