124. 3D-printed hyperelastic bone ® composite scaffolds as bone graft substitutes

Iliac crest bone graft (ICBG) has long been considered the gold standard implant for use in spinal fusion procedures. Due to significant donor site morbidity associated with graft harvest, however, use of ICBG has largely been abandoned in favor of other materials. Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered on an absorbable collagen sponge (ACS; Infuse) is an effective bone graft substitute, but the supra-physiologic doses required to achieve fusion are associated with significant adverse clinical outcomes.
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research

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Authors: Ebrahimi-Zadehlou P, Najafpour A, Mohammadi R Abstract PURPOSE: It is compulsory to make a tension-free, end-to-end repair in transected injuries. However, when it comes to longer defects, placement of an autograft or nerve conduits is required. The present study was designed to assess regenerative potential of silymarin nanoparticles loaded into chitosan conduit on peripheral nerve regeneration in a transected sciatic nerve model in rat. METHODS: In NML group left sciatic nerve was exposed through a gluteal muscle incision and after careful hemostasis skin was closed. In TSC group left sciatic nerve w...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
CONCLUSION: DAAs are effective and safe in the treatment of recurrent HCV infection in LT recipients with history of HCC. Relapse to pre- and post-LT DAA therapy is associated with post-transplantation HCC recurrence. PMID: 33033569 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Publication date: Available online 7 October 2020Source: Arthroscopy TechniquesAuthor(s): CPT. Steven R. Wilding, CPT. Christian A. Cruz, LCDR. Brian J. Mannino, CPT. James B. Deal, CPT Jeffrey Wake, Craig R. Bottoni
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
Conclusion: Addition of intramarrow penetration with DFDBA in surgical periodontal therapy may enhance the healing potential of periodontal intrabony defects, as observed by greater improvement in clinical and radiographic outcomes.
Source: Quintessence International - Category: Dentistry Source Type: research
Conclusions The vomer bone graft has been shown to correct the lateral and inferior disorientation of the alar base and improve the nostril and nasal tip aesthetic measurements. The vomer bone is therefore a sufficient bone source for grafting with high viability and no resorption.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Head and Neck Surgery Source Type: research
A patient affected by a voluminous synovial sarcoma of mediastinum received radical surgery, resulting in injury of both phrenic nerves. Because of the cancer location, reconstruction of the left phrenic nerve was not possible, so to prevent the patient's ventilator dependence, the right phrenic nerve was reconstructed via an autograft from the residual proximal stump of the contralateral one. In 3 months, the right hemidiaphragm function showed a full recovery, documented by ultrasonographic and radiographic assessment of diaphragmatic excursion, and the patient was weaned from mechanical ventilation. When a nerve autogra...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Peripheral Nerve Surgery and Research Source Type: research
Authors: Lee C, Brodke D, Perdue PW, Patel T Abstract The talus is unique in having a tenuous vascular supply and 57% of its surface covered by articular cartilage. Fractures of the head, neck, or body regions have the potential to compromise nearby joints and impair vascular inflow, necessitating surgical treatment with stable internal fixation in many cases. The widely preferred approach for many talar neck and body fractures is a dual anterior incision technique to achieve an anatomic reduction, with the addition of a medial malleolar osteotomy as needed to visualize the posterior talar body. Percutaneous screw ...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
LUNG TRANSPLANTATION, either single or bilateral, involves recipient pneumonectomy followed by implantation and reperfusion of the donor lung. Contemporary approaches to lung transplantation require lung isolation to assist recipient pneumonectomy and donor lung implantation.1 Single-lung transplantation requires interruption of ventilation to the side of allograft transplantation, whereas bilateral lung transplantation involves sequential one-lung ventilation (OLV) when performed without mechanical circulatory support.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Special Article Source Type: research
AbstractPurposeHamstring tendon graft diameter less than 8  mm has been correlated with an increased risk of anterior cruciate ligament reconstruction (ACLR) graft failure. The purpose of this study was to measure and compare the diameter of 3-, 4-, 5-, and 6-strand gracilis and semitendinosus (ST) hamstring tendon (HT) ACLR grafts, and to determine if the re is a correlation between anthropometric data, HT length, and diameter of the HT ACLR graft.MethodsMale patients (n = 78) undergoing primary or revision ACLR with a HT autograft between July 2018 and March 2020 were recruited. Pre-operative anthropom...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
AbstractBackground and objective The main objective was to evaluate the impact of Hepatitis C Virus treatment with direct-acting antiviral agents on tacrolimus blood levels in recipients of kidney and heart allografts.Method We analysed Hepatitis C Virus infected adult patients who received tacrolimus as immunosuppressive maintenance therapy and received direct-acting antiviral agents treatment in a tertiary hospital with solid transplant multidisciplinary program in Madrid, Spain. Liver and renal function, tacrolimus dose and blood levels were analysed before and 12  weeks after the end of treatment.Results We identi...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
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