Approaches to the assessment of severe asthma: barriers and strategies

Source: Journal of Asthma and Allergy - Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

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This study was embedded within the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study. Clinical reference ranges were determined by the 2.5th and 97.5th population-based percentile cut-offs. The associations of UI/Creat with thyrotropin (TSH), free T4 (FT4), free triiodothyronine (FT3), total T4 (TT4), total triiodothyronine (TT3) were studied using multivariable linear regression in TPOAb negative women. The association of UI/Creat with TPOAb and TgAb positivity was analyzed using multivariable logistic regression. RESULTS: Urinary iodine and thyroid function were measured at a medi...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Source: Journal of Asthma and Allergy - Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
While great strides have been made in diagnosing eosinophilic esophagitis (EoE) over the past decade, the journey to diagnosis of eosinophilic gastrointestinal disorders (EGIDs) below the esophagus remains arduous. EGIDs are named after the location of the gastrointestinal tract that is infiltrated by eosinophils. These include eosinophilic gastritis, enteritis, gastroenteritis and colitis. While the prevalence of EGIDs is currently reported to be around 2-5/100,000, it is possible that it is underestimated given the difficulties many EGID patients face before establishing their diagnosis.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Perspective Source Type: research
Non-specific lipid transfer proteins (nsLTPs) are a group of highly conserved, low-molecular-weight proteins that are found throughout the plant kingdom 1. nsLTPs are believed to have an important role in plant defence 2 and are concentrated in the skin of many fruits including those belonging to the Rosaceae family 1,3, of which the peach and it ’s nsLTP Pru p 3 is the most well characterised 1. nsLTP allergy is a common type of food allergy in the Mediterranean, but it is thought to be uncommon in Northern and Central Europe 4.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
We found that multiple outdoor environmental factors (outdoor air pollutants, weather conditions, outdoor aeroallergens, and burden of respiratory virus infections) affect asthma exacerbation events, and these effects differ among the different age groups.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Publication date: Available online 12 September 2019Source: The LancetAuthor(s): R Sharon Chinthrajah, Natasha Purington, Sandra Andorf, Andrew Long, Katherine L O'Laughlin, Shu Chen Lyu, Monali Manohar, Scott D Boyd, Robert Tibshirani, Holden Maecker, Marshall Plaut, Kaori Mukai, Mindy Tsai, Manisha Desai, Stephen J Galli, Kari C NadeauSummaryBackgroundDietary avoidance is recommended for peanut allergies. We evaluated the sustained effects of peanut allergy oral immunotherapy (OIT) in a randomised long-term study in adults and children.MethodsIn this randomised, double-blind, placebo-controlled, phase 2 study, we enrolle...
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionThere is moderate evidence that high doses of ICS, in addition to SCS, reduces the risk of hospital admission in ED treatment of moderate to severe asthma exacerbations. Further research is required to determine their optimal role in both ED and outpatient settings.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 12 September 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jonathan Corren, Mario Castro, Thomas O’Riordan, Nicola A. Hanania, Ian D. Pavord, Santiago Quirce, Bradley E. Chipps, Sally E. Wenzel, Karthinathan Thangavelu, Megan S. Rice, Sivan Harel, Alexandre Jagerschmidt, Asif Khan, Siddhesh Kamat, Jaman Maroni, Paul Rowe, Yufang Lu, Nikhil Amin, Gianluca Pirozzi, Marcella RuddyAbstractBackgroundDupilumab blocks the shared receptor component for interleukin-4 and interleukin-13, key drivers of type 2 inflammation, including immunoglobulin E (IgE)-m...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewUrbanization and urbanization-related detrimental exposures are commonly indicated as responsible determinants for the dramatic increase in allergy and asthma, and one of the main urbanization factors that have been recently associated with the development of allergic sensitization is the reduced access to natural and biodiverse spaces. The present review aimed to compile and discuss the recent findings from studies focused on neighbourhood greenspace effect on asthma and allergic disease development in children.Recent FindingsGreen areas neighbouring children residences play a role on the prevalen...
Source: Current Epidemiology Reports - Category: Epidemiology Source Type: research
ConclusionIn patients with AERD, moderate ‐certainty and high‐certainty evidence shows that aspirin desensitization meaningfully reduces symptoms of rhinosinusitis and improves quality of life, but results in a significant increase in adverse events.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: REVIEW ARTICLE Source Type: research
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