Hidradenitis suppurativa and metabolic syndrome —Systematic review and multivariate-adjusted metaanalysis

Background: Hidradenitis suppurativa (HS) is a debilitating and distressing chronic inflammatory skin disease. Other chronic inflammatory diseases have been linked with metabolic syndrome. However, it is unclear whether this association is independent or driven by underlying risk factors and comorbidities in common, such as obesity, dyslipidemia, hyperglycemia and hypertension.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research

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Abstract Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1R) blockers, current therapies for hypertension and related cardiovascular diseases are still inadequate. Identification of additional components of the RAS and associated vasoactive pathways, as well as new structural and functional insights into established targets, have led to novel therapeutic approaches with the potential to provide improved cardiovascular protection and better blood pressure control and/or reduced adverse side effects. The simultaneo...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Pharmacol Rev Source Type: research
Authors: Dong Y, Li G Abstract Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease in developed countries and is associated with type 2 diabetes mellitus, obesity, hypertension, dyslipidemia, and metabolic syndrome. It is defined as steatosis in over 5% of hepatocytes. The disease spectrum of NAFLD ranges from simple fatty liver to nonalcoholic steatohepatitis, liver fibrosis, even hepatic cirrhosis. The disease affects various extra-hepatic systems such as the cardiovascular system and urinary system. Heart-related disease is identified as the leading cause of mor...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
CONCLUSIONS: HS is associated with a variety of comorbid conditions that should be considered to perform targeted routine screening and to improve HS management. PMID: 30295448 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
The metabolic syndrome —otherwise called syndrome X, insulin resistance syndrome, Reaven syndrome, and “the deadly quartet”—is the name given to the aggregate of clinical conditions comprising central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dy slipidemia. It is a prothrombotic and proinflammatory state characterized by increased inflammatory cytokine activity. In addition to inflammatory dermatoses such as psoriasis, lichen planus, and hidradenitis suppurativa, metabolic syndrome is also commonly associated with accelerated athe...
Source: Clinics in Dermatology - Category: Dermatology Authors: Source Type: research
ConclusionThe application of these recommendations will facilitate the dermatologist practice, and benefit HS patients’ health and quality of life.This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - Category: Dermatology Authors: Tags: Original Article Source Type: research
CONCLUSION: Emerging scientific evidence points to close associations between MetS and common dermatological diseases necessitating to integrate this perspective into clinical management of these diseases. The dermatologist is a key player in early detection of MetS. PMID: 27815622 [PubMed - as supplied by publisher]
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Authors: Lim ZV, Oon HH Abstract Hidradenitis suppurativa is a chronic inflammatory skin condition associated with an increased prevalence of individual metabolic conditions such as insulin resistance, obesity, hyperlipidemia, hypertension, and with the metabolic syndrome, as a constellation of these risk factors. This places affected patients at an increased risk of early cardiovascular morbidity and mortality. Moreover, many of the therapeutic options, including the newer biologics, used in the treatment of hidradenitis suppurativa have both beneficial and adverse metabolic effects. Therefore, it is critical for ...
Source: Annals of Dermatology - Category: Dermatology Tags: Ann Dermatol Source Type: research
Hidradenitis suppurativa (HS) is a chronic inflammatory dermatological disease characterized by nodules, sinus tracts, and subsequent scarring in inverse areas with a prevalence reported from 1-4% [1,2]. HS has been associated with metabolic syndrome, which is a cluster of arterial cardiovascular risk factors i.e. obesity, hypertension, diabetes, and dyslipidemia [3]. Several of these risk factors as well as raised levels of the inflammatory marker C-reactive protein, are also linked to venous thromboembolism i.e.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
ConclusionsWe found an association between HS and diabetes, hyperlipidaemia, obesity, hypertension and metabolic syndrome among a large community‐based cohort of patients with HS. Clinicians should take into account that patients with HS may have one or more undiagnosed components of metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised.
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Epidemiology and Health Services Research Source Type: research
CONCLUSIONS: We found an association between HS and diabetes, hyperlipidemia, obesity, hypertension, and metabolic syndrome among a large community-based cohort of patients with HS. Clinicians should take into account that HS patients may have one or more undiagnosed components of the metabolic syndrome despite their young age. Thus, appropriate targeted screening is advised. This article is protected by copyright. All rights reserved. PMID: 25760289 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
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