Proteomics Links Ubiquitin Chain Topology Change to Transcription Factor Activation

Li et  al. discovered that a chain topology change from K48 to K11 linkages on the transcription factor Met4 reduces competition between the K48 chain and the basal transcription complex for binding to the Met4 tandem UBD. These findings provided insight into the role of ubiquitin chain topologies in ubi quitin signaling.

Source: Molecular Cell - August 19, 2019 Category: Cytology Authors: Yanchang Li, Eric B. Dammer, Yuan Gao, Qiuyan Lan, Mark A. Villamil, Duc M. Duong, Chengpu Zhang, Lingyan Ping, Linda Lauinger, Karin Flick, Zhongwei Xu, Wei Wei, Xiaohua Xing, Lei Chang, Jianping Jin, Xuechuan Hong, Yunping Zhu, Junzhu Wu, Zixin Deng, Fu Tags: Article Source Type: research