Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway

Uroda et  al. identify the structural and functional core of the human lncRNA MEG3, revealing that point mutations designed to disrupt the MEG3 fold impair function. The work proves the importance of lncRNA tertiary structure motifs for selective and specific control of key cellular processes such as the p5 3 stress response.

Source: Molecular Cell - August 19, 2019 Category: Cytology Authors: Tina Uroda, Eleni Anastasakou, Annalisa Rossi, Jean-Marie Teulon, Jean-Luc Pellequer, Paolo Annibale, Ombeline Pessey, Alberto Inga, Isabel Chill ón, Marco Marcia Tags: Article Source Type: research