Strategic room type allocation for nursing wards through Markov chain modeling

Publication date: Available online 19 August 2019Source: Artificial Intelligence in MedicineAuthor(s): Anders Reenberg Andersen, Wim Vancroonenburg, Greet Vanden BergheAbstractProviding patients with the best possible care is the most essential function of any hospital. In an increasing number of countries, hospitals are governed by the number of patients they are able to attract and the corresponding services they provide for patients. One such service, which is often of significant importance for patients, is the option to choose their room type.Hospital decision makers would benefit from a strategic method for optimizing the configuration of room types among nursing wards by distinguishing between patients who prefer private rooms and those who have no preference concerning whether they are assigned to a private or shared room. Such a decision support method is currently non-existent, therefore the goal of this study is to provide a methodology for hospital management. Specifically, a mixed modeling approach is proposed which evaluates the patient flow behavior by applying a Continuous-Time Markov Chain within a heuristic search procedure. This procedure recursively improves a configuration of rooms among the wards by sampling from a gradually improved interpolation of an objective function.Based on patient data obtained from both a Danish and Belgian hospital, the performance and robustness of the proposed approach is validated through various numerical experiments, demon...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research

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Publication date: Available online 14 September 2019Source: Pharmacological ResearchAuthor(s): Rihui Wu, Xueting Mei, Yibiao Ye, Ting Xue, Jiasheng Wang, Wenjia Sun, Caixia Lin, Ruoxue Xue, Jiabao Zhang, Donghui XuAbstractZinc(II) complexes of curcumin display moderate cytotoxicity towards cancer cells at low micromolar concentrations. However, the clinical use of zinc(II) complexes is hampered by hydrolytic insolubility and poor bioavailability and their anticancer mechanisms remain unclear. Here, we investigated the efficacy and mechanism of action of a polyvinylpyrrolidone (PVP-k30)-based solid dispersion of Zn(II)-curc...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
This study sought to answer the question by investigating exogenous GM3 effects on multiple steps involved in atherogenesis. First, the physicochemical properties of native low-density lipoprotein (LDL) and LDL enriched with exogenous GM3 (GM3-LDL) were characterized by dynamic laser scattering, atomic force microscopy, and agarose gel electrophoresis. Then, electrophoretic mobility, conjugated diene and malondialdehyde production, and amino group blockage of GM3-LDL/LDL were measured to determine LDL oxidation degrees and cellular recognition/internalization of GM3-LDL/GM3-oxLDL were detected via confocal microscopy and f...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 September 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Alisa K. Pautova, Pavel D. Sobolev, Alexander I. RevelskyAbstractThe article is devoted to the application of modern sample preparation technique - microextraction by packed sorbent (MEPS) - in conjunction with non-conventional type of sorbent - hypercrosslinked polystyrene, that was investigated for the first time in this work. Their combination was used to extract phenylcarboxylic acid-type aromatic microbial metabolites from serum samples of a healthy volunteer with following derivatization and GC-MS d...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
ConclusionCollectively our data suggest that the bioactive chemical pool which is responsible for the therapeutic effects of EW can be extracted in petroleum ether, and fractionated to a relatively small multiple components. Such components include known anti-inflammatory chemicals, which may contribute to the possible microglia polarization in brain lesion during the recovery of ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsYGY has obvious reversal effects on the abnormal symptoms of adenine-induced CKD and the abnormal symptoms of rats with hypothyroidism and male reproductive hypotension. Its mechanism is related to its ability to regulate the HIF1α-STAT5 pathway.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionWe call for an approach which incorporates a careful design, meticulous execution and a detailed reporting of studies focusing on the pharmacology/bioactivity of bioactive preparations. Clearly testable research questions must be developed and investigated experimentally. As the founder of pharmacology Claude Bernard put it already in 1865: ‘…. either the experimenter's hypothesis will be disproved or it will be proved by experiment. When experiment disproves its preconceived ideas, the experimenter must discard or modify it.‘Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, the bio-composite M-HAP/PSSG is better scaffold for coating on the surface of Ti implant for orthopedic implantation.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionsBoth 18F-HX4 and 18F-FMISO PET/CT can be used as biomarkers for tumor hypoxia and radiotherapy-associated changes. The clinical utilization of these two PET tracers needs to be further validated.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 September 2019Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): A. López-Cabañas
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Publication date: September–October 2019Source: EXPLORE, Volume 15, Issue 5Author(s):
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
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