Korlym (Mifepristone) for Treatment of Endogenous Cushing’s Syndrome

Korlym (mifepristone) is a glucocorticoid receptor blocker indicated for the control of high blood sugar levels in adult patients suffering from endogenous Cushing's syndrome.
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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Background: Nested stromal-epithelial tumor (NSET) is a rare liver tumor, which is most commonly seen in the pediatric age group. To the best of our knowledge, there has been no published review on this rare tumor in the English literature so far.Summary: In this review, we will discuss all the reported details of the published cases, including demography, clinical presentation, molecular histogenesis, imaging, gross pathology and histopathology, immunohistochemical findings, treatment modalities, and outcome of NSET of the liver.Key Message: Thirty-eight cases of NSET have been reported in the last 20 years in the English...
Source: Gastrointestinal Tumors - Category: Gastroenterology Source Type: research
Condition:   Endogenous Cushing's Syndrome Intervention:   Diagnostic Test: Cardiovascular status and quality of life Sponsor:   Wuerzburg University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract AIM: To evaluate clinical comorbidities and steroid use as risk factors for central serous retinopathy (CSR). METHODS: Using national insurance databases, we conducted a case-control study of beneficiaries with an incident diagnosis of CSR between 2007 and 2015 (n=35 492) and randomly selected controls matched on age-based and sex-based propensity scores (n=1 77 460). RESULTS: The mean age (SD) of cases was 49.1 (12.2) years, and the majority (69.2%) were male. Cases were more likely to have received steroids in the past year (OR 1.14, 95% CI 1.09 to 1.19, p
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
CONCLUSIONS: Our data suggest that unilateral adrenalectomy of PBMAH patients leads to clinical remission and a lower incidence of adrenal crisis, but less sufficient biochemical control of hypercortisolism potentially provoking a higher mortality. PMID: 30844071 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
This article describes a newly developed intravenous etomidate infusion protocol for normalizing cortisol levels in patients with severe hypercortisolism.Journal of the Endocrine Society
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Maria M. Pineyro, Lia Redes, Sylvana De Mattos, Luciana Sanchez, Estefania Brignardello, Virginia Bianchi, Vanessa Ems, Dardo Centuri ón, Marcelo Viola
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Chrisoulidou A, Rakitzi P, Boudina M, Apostolidou-Kiouti F, Poimenidou E, Papanikolaou A, Devlioti A, Rallis G, Pazaitou-Panayiotou K Abstract OBJECTIVE: During follow-up in cancer patients, adrenal lesions are frequently found by computer tomography imaging. In these patients, the frequency of subclinical Cushing's syndrome (SCS) has not been fully explored. The aim of the present study was to investigate the presence of SCS in cancer patients with adrenal lesions in comparison to patients with true adrenal incidentalomas. DESIGN: We studied 95 patients with adrenal lesions: 57 patients (group A, 20 m...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Conclusions: After laparoscopic adrenalectomy, the probability of AI is small in patients with adrenal SCS, and the symptoms of AI were mild. Meanwhile, the HPA axis rapidly recovered. Therefore, prophylactic steroid treatment is not mandatory. Given that AI is more frequent in patients with higher cut-offs of 1 mg-DST, a more precise definition of SCS is necessary to better manage these patients.
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - Category: Surgery Tags: Original Articles Source Type: research
Authors: Braun J, Grinshpun A, Atlan K, Sachar S, Knigen A, Yosha-Orpaz L, Grozinsky-Glasberg S, Khoury T, Nachman D Abstract PMID: 30685911 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Jeffrey Wagner, Fabienne Langlois, Dawn Shao Ting Lim, Shirley McCartney, Maria Fleseriu
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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