Impact of obesity, structural severity and their combination on the efficacy of viscosupplementation in patients with knee osteoarthritis

Obesity and radiological severity have been identified to be independent predictors of a low rate of response to viscosupplementation (VS), in patients with knee osteoarthritis (OA). Is that enough to formally...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Research article Source Type: research

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This study was undertaken to quantify the contribution of magnetic resonance imaging (MRI) –evidenced changes in pain‐sensitive structures, bone marrow lesions (BMLs), and synovitis, and changes in pain sensitization or depressive symptoms, to knee pain improvement after substantial weight loss.MethodsMorbidly obese patients with knee pain on most days were evaluated before bariatric surgery or medical weight management and at 1 ‐year follow‐up for BMLs and synovitis seen on MRI, the pressure pain threshold (PPT) at the patella and the right wrist, depressive symptoms (using the Center for Epidemiologic Studies...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
We examined the association of three common chronic conditions (obesity, diabetes mellitus [DM], and cardiovascular disease [CVD]) with transitions among states of hip osteoarthritis (HOA).
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
ConclusionsKT plus quadriceps strengthening exercise does not offer advantages for improvement of pain compared with quadriceps strengthening exercise alone in knee OA.ResumenAntecedentesLos efectos benéficos del ejercicio en el tratamiento de la osteoartritis (OA) de rodilla han sido verificados en varios estudios. El vendaje kinesiológico o kinesiotaping (KT) se ha popularizado debido a la reducción de la presión local y el aumento de la circulación, lo que resulta en disminución del dolor.ObjetivoDeterminar la efectividad clínica de la terapia de fortalecimiento en conjun...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
The relationship between obesity and glenohumeral osteoarthritis is relatively understudied. The purpose of this study was to better define this relationship by age- and gender-matching 596,874 patients across six body mass index (BMI) cohorts and determining the prevalence of glenohumeral osteoarthritis and the standardized rate of glenohumeral arthroplasty in each cohort. Individuals with a BMI over 24 were found to be at increased odds for developing glenohumeral osteoarthritis, compared to the normal BMI cohort, and individuals with a BMI over 30 were additionally found to be at increased odds for undergoing glenohumeral arthroplasty.
Source: Orthopedic Clinics of North America - Category: Orthopaedics Authors: Source Type: research
Nature Reviews Rheumatology, Published online: 16 January 2020; doi:10.1038/s41584-020-0369-5Obesity promotes osteoarthritis (OA) through complex and incompletely understood biomechanical, metabolic and inflammatory factors. New data in mice add to this complexity by showing that eating a high-fat diet increases the risk of OA for two generations of offspring, raising questions about disease mechanisms and future treatment strategies.
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Source Type: research
AbstractPurpose of ReviewDespite perceptions that osteoarthritis only affects older adults, many people develop osteoarthritis before 65  years of age and live decades with pain and disability. It is critical to understand why some adults develop osteoarthritis early in life and the consequences of aging with osteoarthritis.Recent FindingsOver half of people diagnosed with symptomatic knee osteoarthritis are under 65  years of age. Key risk factors are joint injury, certain occupations (e.g., tactical athletes), obesity, and aberrant hip shape. Young adults with osteoarthritis report significant mental health con...
Source: Current Epidemiology Reports - Category: Epidemiology Source Type: research
Adipokines have gained much interest in osteoarthritis (OA) pathogenesis studies over the past years in that they play crucial roles in bone and cartilage homeostasis. Obesity is known to be one of the well-recognized and modifiable causes of OA burden. Key mediators in this metabolic link between obesity and OA could be resistin, among other cytokines secreted by the adipose tissue. We aimed to evaluate the association of serum resistin with obesity, and inflammation in female patients with knee OA.
Source: The Knee - Category: Orthopaedics Authors: Source Type: research
In this study, we investigated the link between AF and senescence markers through the assessment of protein expression in the tissue lysates of human appendages from patients in AF, including paroxysmal (PAF) or permanent AF (PmAF), and in sinus rhythm (SR). The major findings of the study indicated that the progression of AF is strongly related to the human atrial senescence burden as determined by p53 and p16 expression. The stepwise increase of senescence (p53, p16), prothrombotic (TF), and proremodeling (MMP-9) markers observed in the right atrial appendages of patients in SR, PAF, and PmAF points toward multiple inter...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
A rising level of TGF-β has long been associated with numerous aspects of aging. More modern research has shown it to encourage cells to become senescent. Further, TGF-β is an important component of the inflammatory mix of signals secreted by senescent cells, making it a part of the mechanism by which senescent cells can encourage their neighbors to also become senescent. When senescent cells fail to clear quickly, as happens in older individuals, this leads to a feedback loop of continually rising chronic inflammation and ever greater numbers of senescent cells. This is an important contribution to degenerative ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ConclusionsOur findings suggest the existence of homogeneous subgroups of participants and support the utility of identifying patterns of characteristics/risk factors that may cluster together and using them to identify subgroups of people who may be at a higher risk of developing and/or progressing OA.Key Points• Complex interplay among characteristics/factors leads to conflicting evidence between ambulatory activity and knee osteoarthritis.• Distinct subgroups are identifiable based on ambulatory activity, body mass index, knee pain, and comorbidities.• Identifying subgroups can be used to determine those ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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