Continuous terbinafine and pulse itraconazole for the treatment of non-dermatophyte mold toenail onychomycosis.

CONCLUSION: Continuous terbinafine and pulse itraconazole were similar in efficacy for curing NDM onychomycosis. Age was the most consistent prognostic factor affecting likelihood of cure, with factors that may influence drug reaching the site of infection also decreasing likelihood of mycological cure. PMID: 31415182 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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Condition:   Onychomycosis of Toenail Intervention:   Device: Fungal Nail Treatment Kit Sponsor:   Reckitt Benckiser Healthcare (UK) Limited Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report here the results of the 2016 epidemiological survey of dermatomycosis in Japan. In total, 6,776 cases were analyzed as follows: dermatophytosis, 5,772 cases (85.2%); candidiasis, 757 cases (11.2%); Malassezia infection, 235 cases (3.5%); and other fungal infections, 11 cases (0.2%). In dermatophytosis, tinea pedis was the most frequent (3,314 cases: male, 1,705; female, 1,609), followed by tinea unguium (1,634 cases: male, 766; female, 868), tinea corporis (423 cases: male, 241; female, 182); tinea cruris (316 cases: male, 242; female, 74); tinea manuum (58 cases: male, 29; female, 29); tinea capitus, Celsus' ker...
Source: Medical Mycology Journal - Category: Biology Tags: Med Mycol J Source Type: research
Authors: Kawai M Abstract Tinea pedis and tinea unguium are the most common dermatophytoses seen in the daily practice of dermatology. According to a report in Japan Foot Week 2006, it is estimated that about 1 in 5 Japanese have tinea pedis and that about 1 in 10 have tinea unguium. Thus far, use of oral antifungal agents has been the first-line therapy for onychomycosis. Many patients with onychomycosis, however, are elderly and have concomitant diseases as well as liver function disorder. Moreover, oral medications are reportedly associated with risks of impaired liver function and interactions. Due to such risk...
Source: Medical Mycology Journal - Category: Biology Tags: Med Mycol J Source Type: research
As growing the number of aging population and immunocompromised patients, there has been an increase in patients with skin fungal infections. Trichophyton rubrum, Trichophyton mentagrophytes and Candida albicans are known as the key pathogen of superficial dermatomycosis. Although itraconazole, terbinafine, amorolfine, and ciclopirox have been used for the treatment of these infections, they have limitation due to the drug side effects and lack of efficacy. In 2014, the Food and Drug Administration approved efinaconazole as a novel antifungals particular in onychomycosis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetics and Cell Based Therapy Source Type: research
PMID: 31468505 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
AbstractPurpose of ReviewAs both onychomycosis and HIV/AIDS are frequently encountered, we aimed to make a review of the existent information to this moment, including classification, evaluation and treatment.Recent FindingsThe new description of dermatophytes will surely originate changes in the classification and probably in the therapeutic approach. Also, we must be watchful for the modifications that may develop in this pathology with the newer antirretrovirals which are in constant evolution and could modify the patients ’ response to dermatophytosis.SummaryAt this moment, we know that onychomycosis is very comm...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
Onychomycosis is a common disorder that is difficult to cure. It has a prevalence ranging from 2-13% globally, across all age groups. Prevalence is lower in children (0.7%), but athletes are 2.5-fold more likely to develop the disease, with toenail infections 7 times more prevalent than infection of the fingernails. This is a concern for athletes as it can interfere with their performance. The risk of developing onychomycosis is increased by the warm environment of many sports activities, the use of occlusive footwear, the warm, moist environment associated with socks and sweating, shared, close quarters among athletes, an...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Purpose: Onychomatricoma is an uncommon but benign neoplasm of the nail matrix that has been rarely reported in literature and often misdiagnosed. Fewer than 100 cases have been reported, and multiple tumors were initially misdiagnosed and treated as primary onychomycosis. It predominantly affects women (2-16:1) with a peak incidence in the fifth decade with only one pediatric case ever been reported. It is most commonly seen in Caucasians and has a predilection for fingers rather than toes. The classic clinical signs of OM include xanthonychia, nail plate hypertrophy, splinter hemorrhages, transverse overcurvature of the ...
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Background: Tinea unguium, or onychomycosis, is a fungal infection of the nail caused by dermatophytes, yeasts, and nondermatophyte moulds. Effective and efficient treatment is necessary to successfully manage these stubborn infections.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Neodymium-doped yttrium aluminum garnet (Nd:YAG) laser has been reported to be clinically effective for treating onychomycosis. However, there was no report of Nd:YAG laser treatment for the pediatric onychomycosis. Herein, we report a case of Nd:YAG laser treatment in pediatric onychomycosis. An 11-year-old girl presented with palmopalntar keratoderma and dystrophic nails. Microscopic examination of nail scaling before treatment with 20% potassium hydroxide was positive for fungal hyphae. Nails with onychomycosis were treated by 1064 nm Nd:YAG laser and topical epinaconazole.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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