atopic dermatitis: advances in understanding of itch and efficacy of molecular targeted agents.

[ATOPIC DERMATITIS: ADVANCES IN UNDERSTANDING OF ITCH AND EFFICACY OF MOLECULAR TARGETED AGENTS]. Arerugi. 2019;68(7):815-822 Authors: Murota H PMID: 31406075 [PubMed - in process]
Source: Allergology International - Category: Allergy & Immunology Tags: Arerugi Source Type: research

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The D.C. biotech ’s phase 3 clinical trial of a drug candidate failed to reduce symptoms among adult patients with an itchy skin condition called atopic dermatitis.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
AbstractAtopic dermatitis (AD) in older adults (elderly AD) has recently emerged as a newly defined subgroup of AD. When selecting treatment options, clinical characteristics of elderly AD and age-specific factors of older patients must be considered. As in other age groups, regular application of moisturizers in combination with topical corticosteroids and calcineurin inhibitors, adjunctive administration of oral antihistamines/anti-allergic drugs, and avoidance of exacerbating factors comprise basic treatments for elderly AD. For moderate-to-severe cases and/or in those with a decreased ability to use topical treatments,...
Source: Drugs and Aging - Category: Geriatrics Source Type: research
Conclusion: The ADIS is a content valid PRO instrument addressing the concepts critical to the measurement of AD-related itching. To our knowledge, it is the first instrument developed to assess AD-related itch in patients as young as 12 years following the recommendations of the PRO Guidance. PMID: 32037925 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Dermatitis herpetiformis (DH), an itchy blistering skin condition, is considered an extraintestinal manifestation of celiac disease. Both manifestations are driven by the ingestion of dietary gluten, which induces an inflammatory response hallmarked by B- and T-cell activation (Collin et  al., 2017; du Pré and Sollid, 2015). In celiac disease, the gluten-induced T-cell response has been assessed by various means, including an oral three-day wheat challenge coupled with an IFN-γ enzyme-linked immunospot (ELISpot) assay (Anderson et al., 2000; Camarca et al., 2012; Hardy et al., 2015; Tye-Din...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
Dermatitis herpetiformis (DH), an itchy blistering skin condition, is considered an extraintestinal manifestation of celiac disease. Both manifestations are driven by the ingestion of dietary gluten, which induces an inflammatory response hallmarked by B and T cell activation (Collin et al., 2017; du Pr é and Sollid 2015). In celiac disease, the gluten-induced T cell response has been assessed by various means, including an oral three-day wheat challenge coupled with an interferon-γ (IFN-γ) enzyme-linked immunospot (ELISpot) assay (Anderson et al., 2000; Tye-Din et al., 2010a; Camarca et al., 20 12; Hardy et al., 2015).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
Abstract Dermatitis herpetiformis (DH) is an autoimmune skin disease that causes itchy, blistering rash, typically on the elbows, knees and buttocks. DH and coeliac disease share the same genetic background, gluten-dependent enteropathy and antibody response against tissue transglutaminase. DH is currently considered a cutaneous manifestation of coeliac disease, and the prevailing hypothesis is that DH develops as a late manifestation of subclinical coeliac disease. The incidence of DH is decreasing contemporarily with the increasing incidence of coeliac disease. The IgA immune response in DH skin is directed agai...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
In this study, we investigated the peripheral and spinal mechanisms responsible for prolonged itch in a mouse model of allergic contact dermatitis (ACD) induced by squaric acid dibutylester (SADBE). We found that repeated exposure of mice to SADBE evoked persistent spontaneous scratching and significantly aberrant cutaneous and systemic immune responses lasting for weeks.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Seborrhoeic dermatitis is a skin condition in which the scalp becomes red, itchy and flaky. It's very common - occurring in around one in 25 people. It can affect any area of oily skin.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Abstract BACKGROUND: Sleep disturbances (SD) are common in adults with atopic dermatitis (AD). Patient-Reported Outcomes Measurement Information System (PROMIS™) SD and Sleep-Related Impairment (SRI) are validated questionnaires to assess sleep in adults. Little is known about their measurement properties in adults with AD. OBJECTIVE: To assess the measurement properties of PROMIS SD and SRI 8-item short-forms in AD. METHODS: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n=420). RESULTS: PROMIS SD/SRI showed moderate correla...
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Authors: Kaaz K, Szepietowski JC, Matusiak Ł Abstract Chronic dermatoses, including atopic dermatitis, psoriasis, prurigo nodularis, chronic spontaneous urticaria and hidradenitis suppurativa, as well as accompanying subjective symptoms (itch and pain), have a great impact on patients' well-being. Skin plays an important role in the physiological sleep process. This review attempts to analyze the association between chronic dermatoses in adults and sleep quality in recent studies. Polysomnography and actigraphy are performed for the objective assessment of sleep quality. Questionnaire-based subjective evaluations ...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
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