Fluorescent light energy: A new therapeutic approach to effectively treating acne conglobata and hidradenitis suppurativa
The Kleresca® biophotonic platform utilizing fluorescent light energy (FLE) effectively treated both acne conglobata and hidradenitis suppurativa. FLE decreased the presence of inflammatory nodules, cysts, and associated erythema. It also supported a healing response to improve skin texture. FLE offers a new treatment approach to recalcitrant inflammatory skin conditions. AbstractThe Kleresca® biophotonic platform utilizing fluorescent light energy (FLE) effectively treated both acne conglobata and hidradenitis suppurativa. FLE decreased the presence of inflammatory nodules, cysts, and associated erythema. It also supported a healing response to improve skin texture. FLE offers a new treatment approach to recalcitrant inflammatory skin conditions.
Hidradenitis suppurativa (HS), also known as acne inversa, is an incapacitating skin disorder of unknown etiology manifested as abscess-like nodules and boils resulting in fistulas and tissue scarring as it progresses. Given that neutrophils are the predominant leukocyte infiltrate in HS lesions, the role of neutrophil extracellular traps (NETs) in the induction of local and systemic immune dysregulation in this disease was examined. Immunofluorescence microscopy was performed in HS lesions and detected the prominent presence of NETs. NET complexes correlated with disease severity, as measured by Hurley staging. Neutrophil...
A more reliable classification of skin inflammation and severity of active disease results by ultrasound sonography and the new HS classification system IHS4. However, an objective assessment of skin inflammation in a continuous mode is still the ultimate goal. Long-wave Medical Infrared Thermography (MIT) may offer a blood flow and temperature differential assessment in inflammatory conditions. This project was designed to evaluate the application of MIT in HS. Standardised photography of the areas involved or been candidate for HS involvement and MIT pictures of 18 patients [11 female, 7 male, median age 38.75 years (95%...
Hidradenitis suppurativa/acne inversa (HS) is a chronic, recurrent skin disease of the hair follicle. It manifests with painful, deeply localized, inflammatory skin lesions that occur in apocrine gland-rich areas of the skin, most commonly in the axillae and the inguinal and anogenital regions (Dessauer definition). The central pathogenic event in HS is believed to be the occlusion of the hair follicle leading to a perifollicular lymphohistiocytic inflammation. The purpose of this work was to develop a human HS model which could help to understand the pathophysiology of HS and to determine the action of therapeutic candidates.
In this study we investigated the expression and localization of the transglutaminase inhibitory proteins (SERPINB3/B4) and the antimicrobial proteins (S100A7-A9) in HS. Comparative analysis of gene expressi on in the lesional vs healthy appearing skin from microarray data of 8 affected patients and 4 healthy individuals showed 705 statistically significant upregulated genes and 482 downregulated (fold change>2, p
Acne inversa, also known as hidradenitis suppurativa (HS), is a neglected, prevalent, chronic, stigmatizing, and debilitating inflammatory skin disease. HS patients suffer from deep, painful, recurrent abscesses that drain malodorous fluid and lead to disfiguring scars that can limit mobility of the arms and legs. People with African ancestry have a more than two-fold increased risk of HS. A lack of effective therapies and limited knowledge about HS pathogenesis contribute to unmet needs. Unlike other common inflammatory skin diseases, there never has been a genome-wide association study (GWAS) conducted for HS.
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Title: Hidradenitis Suppurativa (Acne Inversa)Category: Diseases and ConditionsCreated: 8/14/2018 12:00:00 AMLast Editorial Review: 8/23/2019 12:00:00 AM
Introduction: Acne inversa (hidradenitis suppurativa), a chronic inflammatory skin disease, has been associated with impaired quality of life. There are various measuring systems to assess physical severity; however, there are no specific quality of life questionnaires for this disease in the Spanish language.
Introduction: Hidradenitis suppurativa (HS) has been shown to have a negative impact on quality of life, even more so than psoriasis, acne and eczema. Research has only recently focused on the impact HS has on sexual health. HS patients may experience sexual decline due to pain, physical appearance, and diminished sexual desire. Dermatologists who treat this chronic condition are in a unique position to screen these patients for sexual health concerns and provide counseling or specialized referral
We present a 24 year old female with a 4 year history of hidradenitis suppurativa (HS) and nodulocystic acne who developed vitiligo 4 mon ths after commencing adalimumab. Anti TNF therapy has been successfully used in other diseases, where the development of vitiligo has been noted in case reports.