The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing

Historically, histone deacetylases have been described as inhibitors of transcription initiation by compacting chromatin at the transcriptional starting site. Etchegaray et  al. identified the histone deacetylase SIRT6 as a critical modulator of transcriptional pausing and elongation, acting downstream of recruitment of Pol II.

Source: Molecular Cell - August 5, 2019 Category: Cytology Authors: Jean-Pierre Etchegaray, Lei Zhong, Catherine Li, Telmo Henriques, Eileen Ablondi, Tomoyoshi Nakadai, Capucine Van Rechem, Christina Ferrer, Kenneth N. Ross, Jee-Eun Choi, Ann Samarakkody, Fei Ji, Andrew Chang, Ruslan I. Sadreyev, Sridhar Ramaswamy, Sergei Tags: Article Source Type: research