Correction to Lancet Diabetes Endocrinol 2019; 7: 515–27

Publication date: Available online 15 July 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s):
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research

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Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening hypoglycemia during starvation-like conditions, but do not consistently exhibit overt metabolic phenotypes when given ad libitum food access. These results, and findings of ghrelin resistance in obese states, imply nutritional state dependence of ghrelin’s metabolic actions. Here, we hypothesized that liver-enriched antimicrobial peptide-2 (LEAP2), a recently characterized endogenous GHSR antagonist, blunts ghrelin action during obese states and pos...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
In a society where physical activity is limited and food supply is abundant, metabolic diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster of metabolically related symptoms such as obesity, hypertension, dyslipidemia, and carbohydrate intolerance, and significantly increases type 2 diabetes mellitus risk. Insulin resistance and hyperinsulinemia are consistent characteristics of MetS, but which of these features is the initiating insult is still widely debated. Regardless, both of these conditions trigger adverse responses from the pancreatic β cell, which is responsible for produci...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
This study aimed to explore the association between thyroid dysfunction and OSA in the adults with prediabetes or diabetes mellitus type 2, who have very high prevalence of OSA.MethodsOSA was assessed using an in-home monitoring device, WatchPAT200. OSA severity was measured using apnea-hypopnea index (AHI), oxygen desaturation index (ODI), minimum oxygen saturation (minO2), and time spent under oxygen saturation
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
ABSTRACT Purpose: To compare the intravitreal concentrations of cellular mediators involved in neurodegeneration, inflammation, and angiogenesis in patients with proliferative diabetic retinopathy and other vitreoretinal diseases. Methods: A multiplex bead immunoassay was used to measure vitreous levels of pigment epithelium-derived factor, serum amyloid P, C-reactive protein, complement C4, alpha-1 antitrypsin, vascular endothelial growth factor, platelet-derived growth factor-AA, platelet-derived growth factor-BB, interleukin-6, interleukin-8, interleukin-10, tumor necrosis factor alpha and beta in patients undergoing 23...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research
Conclusion: Our results suggest that panretinal photocoagulation does not cause morphological optic disk changes in patients with diabetic proliferative retinopathy after 1 year of follow-up.RESUMO Objetivo: Determinar o efeito da panfotocoagula ção retiniana nos parâmetros topográficos do disco óptico em pacientes não glaucomatosos com retinopatia diabética proliferativa. Métodos: Este é um estudo observacional pros­pectivo e unicêntrico. Trinta e oito olhos de 26 pacientes dia­béticos foram submetidos à panfotocoagulaçã...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research
FINDINGSA UCLA study revealed that a gene on the X chromosome may help explain why more women than men develop multiple sclerosis and other autoimmune diseases. Researchers found that a gene known as  Kdm6a was expressed more in women’s immune cells than in men’s, and expressed more in female mice than in males.When the Kdm6a gene was eliminated in mice that were bred to mimic a disease like MS, they had improved symptoms, reduced inflammation and less damage to their spinal cords.BACKGROUNDWomen ’s risk of developing MS is about three times greater than men’s, and women have stronger immu...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
DiabetesMine explains the basics of CGM (continuous glucose monitors), how to choose one, costs, insurance coverage, and where to buy.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
Many patients with type 2 diabetes are overtreated, leading to more than 9000 preventable hospital visits over 2 years, a modeling study found.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
Yale Medicine experts provide a road map to help teenagers manage their condition.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
ConclusionThese findings suggested that C. inerme leaves have potent antidiabetic and anti-oxidant activities. The results provide reliable scientific base, which is the premise for further research and development of CILE as supplements.
Source: Chinese Herbal Medicines - Category: Complementary Medicine Source Type: research
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