Medical News Today: Everything you need to know about methylphenidate

Methylphenidate is a stimulant drug that doctors prescribe to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Learn about how it works, its side effects, and typical dosages here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: ADHD / ADD Source Type: news

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Epilepsy Behav. 2021 Sep 14;124:108311. doi: 10.1016/j.yebeh.2021.108311. Online ahead of print.ABSTRACTExcessive daytime sleepiness (EDS) and attentional deficits are often observed in people with epilepsy. They may be the consequence of seizures and subclinical discharges as well as of comorbid conditions as obstructive sleep apnea/hypopnea syndrome (OSAS), attention deficit hyperactivity disorder (ADHD), or other less frequent disorders. Excessive daytime sleepiness may also be caused or worsened by antiseizure medications (ASMs). Several meta-analyses suggested that lamotrigine, lacosamide, and perhaps eslicarbazepine ...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Source Type: research
On the one hand, amphetamine (racemic D,L-amphetamine, ratio 1:1) is used as an illegal drug; but on the other hand, especially D-amphetamine serves to treat narcolepsy and preferentially activity deficiency/ hyperactivity disorder (ADHD). Recently, in Ger...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
J Sleep Res. 2021 Jun 24:e13426. doi: 10.1111/jsr.13426. Online ahead of print.ABSTRACTThe analysis of sleep microstructure in attention deficit hyperactivity disorder (ADHD) revealed an under-representation of the EEG slow component during NREM sleep. Previous studies either excluded or did not characterize objectively sleep disorders, which notoriously affect sleep architecture. The present study aimed to investigate the cyclic alternating pattern in a real clinical sample of children with ADHD, in whom sleep disorders could be considered. Twenty-seven consecutively enrolled drug-naïve children (mean age, 10.53 year...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Source Type: research
ConclusionsAt present, there is a lack of disease-specific and validated questionnaires for pediatric narcoleptic patients. This need can be met by modifying and adjusting the existing adult questionnaires and developing new questionnaires for pediatric narcoleptic patients.
Source: Italian Journal of Pediatrics - Category: Pediatrics Source Type: research
Amphetamine is a potent psychostimulant also used to treat attention deficit/hyperactivity disorder and narcolepsy. In vivo and in vitro data have demonstrated that amphetamine increases the amount of extra synaptic dopamine by both inhibiting reuptake and promoting efflux of dopamine through the dopamine transporter. Previous studies have shown that chronic use of amphetamine causes tolerance to the drug. Thus, since the molecular mechanisms underlying tolerance to amphetamine are still unknown, an animal model to identify the neurochemical mechanisms associated with drug tolerance is greatly needed. Here we took advantag...
Source: Brain, Behavior and Evolution - Category: Neurology Source Type: research
CONCLUSIONS: Our findings suggest that modafinil could act on the right thalamus, changing the behavior and brain function associated with auditory emotional processing. These results indicate that modafinil could change emotional recognition by reducing emotional activation related to social communication.PMID:33692297 | DOI:10.1272/jnms.JNMS.2021_88-607
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Source Type: research
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