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‘Bloodless’ Lung Transplants for Jehovah’s Witnesses

Hospitals are working to further innovate “bloodless” operations, both to treat those who shun transfusions and to advance techniques for all patients.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Blood Donation Doctors Tomczak, Rebecca S. Transplants Lungs Jehovah's Witnesses Medicine and Health Wal-Mart Stores Inc WMT NYSE Religion and Belief Source Type: news

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In this study, we identified a novel anti-inflammatory effect of miR-199b-5p (miR-199b) through the GSK3 β and NF-κB pathways. THP-1 monocytes treated with LPS showed a significant decrease in miR-199b that is inversely correlated to GSK3β expression and NF-κB activation. Furthermore, the NF-κB-associated inflammatory response was reduced due to the overexpression of miR-199b targeting GSK3β, whi ch was rescued by the inhibition of miR-199b. These results indicated that miR-199b attenuated the inflammatory response at least partly through the GSK3β/NF-κB signaling pathways in mon...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
In conclusion, toxic cytokine and HMGB1 released from failing small-for-size grafts leads to pulmonary adhesion molecule expression, leukocyte infiltration and injury. IP prevents DAMP release and toxic cytokine formation in small-for-size grafts, thereby attenuating ALI. PMID: 29755641 [PubMed]
Source: International Journal of Physiology, Pathophysiology and Pharmacology - Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research
DEEP VENOUS THROMBOSIS (DVT) and pulmonary embolism (PE) are relatively common postoperative complications in the surgical patient population. Estimates of the incidence of DVT and/or PE in the lung transplant population vary significantly. A recent Nationwide Inpatient Sample inquiry estimated that venous thromboembolism (VTE) is diagnosed in 6.3% of lung transplant recipients during their index admission for transplantation, with DVT alone diagnosed in 5.4%, or concurrent with PE in 1.1%.1 However, this statistic is based primarily on reported diagnosis codes and may not capture all cases of interest.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Case Report Source Type: research
Clinical Transplantation, EarlyView.
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Source Type: research
Severe right ventricular failure necessitating a RVAD complicates 6-11% of LVAD implants. Patient outcomes for those receiving durable continuous-flow VADs in a biventricular configuration (i.e. BiVAD) have been reported in limited case series.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Conditions:   Cognitive Impairment;   Pulmonary Rehabilitation Intervention:   Other: Pulmonary Rehabilitation Sponsor:   Istanbul Medipol University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Intestinal ischemia-reperfusion (I/R) occurs in various clinical settings, such as transplantation, acute mesenteric arterial occlusion, trauma and shock. I/R injury causes severe systemic inflammation, leading to multiple organ dysfunction associated with high mortality. The ubiquitin proteasome pathway has been indicated in the regulation of inflammation, particularly through NF-κB signaling pathway. PYR-41 is a small molecular compound that selectively inhibits ubiquitin-activating enzyme E1. A mouse model of intestinal I/R injury by clamping the superior mesenteric artery for 45 minutes was perf...
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
Conclusions Well-controlled maximum back strength testing is feasible and reliable, and the scores are highly correlated with grip strength in lung transplant recipients shortly before hospital discharge. The Biering-Sørensen test should be limited to patients without dominant weakness and/or fear. Future research should investigate whether grip instead of back extension strength can safely be used for proper exercise prescription.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
I was talking with someone recently about grief when she said that it felt like being on a roller coaster ride. This person is facing the impending death of a loved one even as there is no definitive timeline per the treatment team. We spoke of the dynamic of anticipatory grief and the ways in which it impacts the process of letting go of this person as she plans her future in the face of his eventual absence. I have found both in my therapeutic practice and in my personal life, that anticipatory grief genuinely effects mourners, although a 2006 article published in the Counseling, Psychology, and Health Journal quest...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Family Grief and Loss Health-related Interview Peer Support Personal anticipatory grief Cancer grieving Mourning widow widower Source Type: blogs
Purpose of review Within the United States, donor heart and lung procurement varies between institutions and among surgeons within the same institution sometimes. The purpose of this article is to review the history of donor heart and lung procurement, the surgical techniques, and pitfalls. Recent findings The current article covers the important intraoperative evaluation of the donor heart and lungs at the procurement hospital and the surgical pitfalls that can be prevented to ensure good procurement of donor heart and lungs. Summary The current article provides a review of the history of donor procurement. The ar...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: THORACIC TRANSPLANTATION: Edited by Abbas Ardehali Source Type: research
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