Severity staging of hidradenitis suppurativa: is Hurley classification the answer?
Severity staging of hidradenitis suppurativa: is Hurley classification the answer? Br J Dermatol. 2019 Jul 07;: Authors: Thorlacius L PMID: 31281960 [PubMed - as supplied by publisher]
This study aimed to evaluate systemic inflammation in patients with HS by assessing serum amyloid A protein (SAA) and C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR) and to identify potential risk factors for HS. Forty-four patients (M/F: 28/16) and 44 age- and sex-matched controls (M/F: 28/16) were enrolled. Demographic, clinical, laboratory, and therapeutic data, including smoking status, body mass index (BMI), waist circumference (WC), serum fasting lipid profile, fasting blood glucose, SAA, and CRP levels, and ESR were assessed. Associations were investigated by univariate and multivariate anal...
This cohort study compares the risk of myocardial infarction, cerebrovascular accident, and composite disease in patients with hidradenitis suppurativa.
AbstractHidradenitis Suppurativa (HS) is a chronic, inflammatory, and relapsing skin disease. Pathogenesis of the disease is not well understood, but many studies revealed the potential role of cytokines and interleukins. IL-36 expression was increased in tissue samples of HS patients with conflicting result regarding serum levels. To investigate serum IL-36 levels in HS patients and evaluate their relation to disease characteristics, 44 patients diagnosed with HS and 44 age and sex-matched healthy controls were included in the study. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum IL-36 concentrations....
Abstract Hidradenitis suppurativa (HS) is an inflammatory skin condition affecting skin fold regions. HS is associated with a marked reduction in quality-of-life (QoL), financial burden,1 and high incidence of comorbid mental illness.2 This disease begins in early adulthood, a time of psychiatric vulnerability and immense professional growth. This is a critical time in planning careers and establishing social contacts that overtime may change an individual's life course.3 However, there is limited research on HS's impact on employment and work productivity. PMID: 31707731 [PubMed - as supplied by publisher]
DISCUSSION: The HiSQOL is a reliable and valid instrument to measure HS-specific HRQOL for clinical trials. PMID: 31705538 [PubMed - as supplied by publisher]
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful deep-seated recurrent nodules and abscesses in axillary, inguinal and perineal areas (Jemec, 2012). It is a complex disease with an aetiology including genetic variations, environmental factors and aberrant innate and adaptive immune functions (Alikhan et al., 2009, Kelly et al., 2014, Moran et al., 2017).
Abstract Hidradenitis suppurativa is a chronic folliculitis affecting intertriginous areas. Onset generally occurs in young adulthood to middle adulthood (18 to 39 years of age). Females and blacks are more than twice as likely to be affected. Additional risk factors include family history, smoking, and obesity. Hidradenitis suppurativa is associated with several comorbidities, including diabetes mellitus and Crohn disease. The clinical presentation of hidradenitis suppurativa ranges from rare, mild inflammatory nodules to widespread abscesses, sinus tracts, and scarring. Quality of life is often affected, and pat...
Is this modified approach based on the TIME concept useful in the topical management of hidradenitis suppurativa?Wounds