Comparable Efficacy and Safety of Brodalumab in Obese and Non-Obese Patients With Psoriasis: Analysis of 2 Randomized Controlled Trials.

Comparable Efficacy and Safety of Brodalumab in Obese and Non-Obese Patients With Psoriasis: Analysis of 2 Randomized Controlled Trials. Br J Dermatol. 2019 Jul 05;: Authors: Hsu S, Green LJ, Lebwohl MG, Wu JJ, Blauvelt A, Jacobson AA Abstract BACKGROUND: Obesity is associated with psoriasis and negatively affects response to therapy. OBJECTIVE: To evaluate efficacy and safety of brodalumab in non-obese vs obese patients with psoriasis. METHODS: In this post hoc analysis of the prospective, phase 3, multicentre, randomized, placebo- and active comparator-controlled AMAGINE-2 and AMAGINE-3 trials, patients were randomized to treatment with brodalumab 210 mg every 2 weeks, ustekinumab, or placebo for a 12-week induction phase. At week 12, patients who received brodalumab 210 mg Q2W continued brodalumab, those treated with ustekinumab continued ustekinumab, and those who received placebo switched to brodalumab 210 mg every 2 weeks. Patients were categorized by body mass index (BMI) category (
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Conclusion: PsA is characterized by an increase in cardiovascular morbidity in relation with insulin resistance. Current treatments seem to improve this risk with a decrease in cardiovascular mortality in comparison with patients with plaque psoriasis but this requires confirmation in larger prospective studies.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewThe purpose of this review article is to provide an overview of sleep and pulmonary comorbidities in patients with psoriasis and summarize important recent findings.Recent FindingsEvidence continues to show that patients with psoriasis experience greater chronic sleep impairment when compared to healthy counterparts. In addition to other comorbidities seen in psoriasis patients, including cardiovascular disease, obesity, and diabetes, obstructive sleep apnea and chronic obstructive pulmonary disease have increased frequency in this population.SummarySleep and pulmonary comorbidities in psoriasis co...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
Conclusions: Liraglutide can improve psoriasis skin lesions of obese diabetic mice, and the mechanism may be related to the inhibition of the expression of IL-23, IL-17, IL-22, and TNF-α through the IL-23/Th-17 pathway. PMID: 31868553 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
AbstractCurrent evidence suggests that there are notable differences in the severity of psoriasis between racial and ethnic groups. While the US Latino population is growing rapidly, there is little research on the various factors impacting disease severity in this minority population. This review evaluates the current evidence on psoriasis in Latinos within the US. Psoriasis affects the US Latino population at a lower prevalence, with more severe disease and a greater quality-of-life impact than their White counterparts. In addition, Latinos with psoriasis experience higher rates of comorbidities, such as depression, obes...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Authors: Dalmády S, Kemény L, Antal M, Gyulai R Abstract Introduction: Psoriasis is a chronic autoimmune skin disease with strong genetic background and environmental triggers. Patients with psoriasis and psoriatic arthritis are at greater risk of developing other chronic and potentially severe comorbidities, such as psoriatic arthritis, hyperlipidemia, type 2 diabetes mellitus, obesity, metabolic syndrome, cardiovascular diseases or depression. Recently, accumulating epidemiologic, genetic and pathogenetic evidence indicates that psoriasis is also associated with periodontitis, a chronic progressive ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
This review examined the impact of weight loss on pre-existing psoriasis or psoriatic arthritis. Might losing weight prevent the onset of psoriasis in obese individuals?The British Journal of Dermatology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news
Conditions:   Rheumatoid Arthritis;   Psoriatic Arthritis;   Arthritis;   Psoriasis;   Cardiovascular Diseases;   Obesity;   Lung Diseases Intervention:   Other: Care as usual Sponsor:   Vastra Gotaland Region Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: The prevalence of MetS in patients with psoriasis in Singapore was 45.3%, or nearly threefold higher than the Singapore general population. Patients with psoriasis should be screened yearly for MetS and any modifiable cardiovascular risk factors should be actively controlled. PMID: 31788703 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - Category: General Medicine Authors: Tags: Singapore Med J Source Type: research
We examined the research evidence that was available up to July 2018, and identified 10 relevant randomised trials, with a total of approximately 1,200 participants. The quality of evidence was moderate to low, with study limitations including participants knowing which treatment they were receiving and a large number of withdrawals from the trials.However, we were able to draw some conclusions. We found that among obese patients with psoriasis, dietary intervention with a low-calorie diet may reduce the severity of psoriasis, and probably improves their quality of life and reduces their body mass index, or BMI. Also, amon...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
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