[Increased Clozapine Levels During Infection: more Frequent than Assumed?]

[Increased Clozapine Levels During Infection: more Frequent than Assumed?] Psychiatr Prax. 2019 Jul;46(5):287-289 Authors: Wilkening A, Palm U Abstract Systemic infections are known to alter the metabolism of various drugs via inhibition of the cytochrome P450 family. Here, we report the cases of two patients with schizophrenic psychosis and highly elevated clozapine levels during pulmonary systemic infection, however without experiencing side effects. After antibiotic treatment and temporary reduction of clozapine dosage blood levels of clozapine normalized within a few days. These cases show that clozapine levels may be highly elevated without necessarily causing side effects and that intensified pharmacovigilance should be considered by the clinician in patients with systemic infections. PMID: 31269521 [PubMed - in process]
Source: Psychiatrische Praxis - Category: Psychiatry Tags: Psychiatr Prax Source Type: research