Comment on: Unacylated ghrelin is correlated with the decline of bone mineral density after Roux-en-Y gastric bypass in obese Chinese with type 2 diabetes

This study sheds new light on the complex changes in bone metabolism and, ultimately, bone density after metabolic surgery.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Editorial comment Source Type: research

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This study will evaluate whether neurostimulation can automatically respond to the signals that occur immediately before a loss-of-control eating episode to help patients regain control, a potentially groundbreaking intervention for the most severely affected patients. The RNS System’s ability to continuously monitor brain activity and respond with therapy when these biomarkers are detected makes the system an ideal fit for this research.” Changes in the Market With this study, NeuroPace is venturing out into new territory. Typically, the firm’s closed-loop neuromodulat...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
ConclusionThe results show the benefits of MGB/OAGB in mild obese diabetic patients.
Source: Obesity Surgery - Category: Surgery Source Type: research
Authors: Justinussen T, Madsbad S, Holst JJ, Bojsen-Møller KN Abstract Introduction: The worldwide prevalence of obesity and type 2 diabetes (T2D) constitutes an epidemic that is a threat to public health. Bariatric surgery, including Roux en-Y gastric bypass (RYGB), is currently the most effective treatment to induce long-term weight loss and remission of co-morbid conditions. Surgery, however, comes with an added risk of complications, highlighting the need to understand the comparative effectiveness and risks of surgical versus conventional approaches to the treatment of obesity and T2D. Areas covered: Po...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionWe present a comprehensive mRNA expression profile of chromogranin A positive enteroendocrine cells following RYGB in rats. The data provides a region-specific characterization of all regulated preprohormone encoding genes in the rat GI tract including 16 not hitherto known. The comprehensive catalogue of preprohormone expression changes may support our understanding of hormone mediated effects of RYGB on diabetes remission and body weight reduction.Graphical abstract
Source: Peptides - Category: Biochemistry Source Type: research
Conclusionclinicians should be aware of such condition in patients with history of bariatric surgery who present with long-standing, intermittent abdominal pain.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 4 June 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Alexander Dimitri Miras, Belén Pérez-Pevida, Madhawi Aldhwayan, Anna Kamocka, Emma Rose McGlone, Werd Al-Najim, Harvinder Chahal, Rachel L Batterham, Barbara McGowan, Omar Khan, Veronica Greener, Ahmed R Ahmed, Aviva Petrie, Samantha Scholtz, Stephen R Bloom, Tricia M TanSummaryBackgroundMany patients with type 2 diabetes do not achieve sustained diabetes remission after metabolic (bariatric) surgery for the treatment of obesity. Liraglutide, a glucagon-like peptide-1 analogue, improves glycaemic control and...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
This study sheds new light on the complex changes in bone metabolism and ultimately bone density after metabolic surgery.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
The foregut theory posits that proximal small intestine plays an important role in the improvement of type 2 diabetes (T2D) after Roux-en-Y gastric bypass (RYGB).
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
Gastric bypass surgery leads to dramatic weight loss and improvement in insulin resistance to the point of the resolution of type 2 diabetes in a majority of cases. These improvements in insulin sensitivity appear to be weight loss independent and occur immediately after bariatric surgery. The focus of the current review will be to summarize how the physiological changes that have been shown to arise from sustained weight loss after bariatric surgery affect other interrelated endocrine processes such as bone remodeling and improve obesity ‐related hypogonadal dysfunction. AbstractBariatric surgery is now the most widely ...
Source: Physiological Reports - Category: Physiology Authors: Tags: Invited Review Source Type: research
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