Hsp70 molecular chaperones: multifunctional allosteric holding and unfolding machines

The Hsp70 family of chaperones works with its co-chaperones, the nucleotide exchange factors and J-domain proteins, to facilitate a multitude of cellular functions. Central players in protein homeostasis, these jacks-of-many-trades are utilized in a variety of ways because of their ability to bind with selective promiscuity to regions of their client proteins that are exposed when the client is unfolded, either fully or partially, or visits a conformational state that exposes the binding region in a regulated manner. The key to Hsp70 functions is that their substrate binding is transient and allosterically cycles in a nucleotide-dependent fashion between high- and low-affinity states. In the past few years, structural insights into the molecular mechanism of this allosterically regulated binding have emerged and provided deep insight into the deceptively simple Hsp70 molecular machine that is so widely harnessed by nature for diverse cellular functions. In this review, these structural insights are discussed to give a picture of the current understanding of how Hsp70 chaperones work.
Source: Biochemical Journal - Category: Biochemistry Authors: Tags: Review Articles Source Type: research

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Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
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Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
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Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
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Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
Publication date: Available online 17 July 2019Source: Global HeartAuthor(s): Jessica Ying-Yi Xie, Matthew R. Solomons, Mahmood Ahmad
Source: Global Heart - Category: Cardiology Source Type: research
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Source: American Heart Journal - Category: Cardiology Source Type: research
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Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
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Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
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Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
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Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
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