Pathophysiology of Diabetic Erectile DysfunctionPathophysiology of Diabetic Erectile Dysfunction
Learn more on the mechanisms leading to erectile dysfunction in diabetes. International Journal of Impotence Research
In this study, we investigated the effects of Eucommia ulmoides Oliv. leaf extract (EULE) on restoring erectile function in streptozotocin (STZ)-induced diabetic rats model. After 16 weeks of treatment, EULE administration had significantly increased intracavernosal pressure, nitric oxide (NO) levels, and cyclic guanosine monophosphate (cGMP) concentrations. Serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels were markedly higher and serum malondialdehyde (MDA) levels were lower in the EULE-treated groups than in the diabetic model group. EULE restored NO biosynthesis by significantly increasing pro...
The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat, Published online: 12 April 2019; doi:10.1038/s41443-019-0137-8The effect of Ferula elaeochytris root extract on erectile dysfunction in streptozotocin-induced diabetic rat
Conclusion: Among men with type 1 diabetes not using antihypertensive medications, higher SBP is associated with increased risk of developing erectile dysfunction. These findings provide evidence to support further investigation into the potential benefit of early blood pressure control on risk of erectile dysfunction in men with diabetes regardless of age, blood pressure level, or glycemic control.
CONCLUSION: The most predictive factor of 3yED was the dose to the PB. This may be explained by variation in individual patients' anatomy and this could allow for the development of better strategies to prevent ED. PMID: 30761939 [PubMed - as supplied by publisher]
ConclusionIn patients with Leriche ’s syndrome, revascularization of the profunda femoris artery (profundoplasty) ameliorates vasculogenic impotence through the improvement of the pelvic blood flow via the collateral circulation.
Prevalence and correlates of erectile dysfunction in type 2 diabetic men: a population-based cross-sectional study in Chinese men, Published online: 13 August 2018; doi:10.1038/s41443-018-0060-4Prevalence and correlates of erectile dysfunction in type 2 diabetic men: a population-based cross-sectional study in Chinese men
By age 60, you have a 50/50 chance of having a clinically enlarged prostate. And it only gets worse every year. When your prostate isn’t functioning properly, it’s hard to enjoy life. Traditional doctors give you two choices. Go under the knife or you take Big Pharma’s drugs. Either way, you have a good chance of ending up with your manhood on the line… If you have surgery, there’s a big risk you’ll be saying goodbye to your sex life for good. The rate of impotence is a shocking 50 to 60% after prostate surgery.1 Big Pharma’s meds to shrink your prostate are no better. These sy...
This study was designed to investigate the effect of Swietenia macrophylla (SM) and Anogeissus leiocarpus (AL) extracts on enzymes relevant to erectile dysfunction (phosphodiesterase‐5 and arginase) and type‐2 diabetes (α‐amylase and α‐glucosidase), assess their antioxidant potential and characterize their phenolic constituents. The results revealed that extracts inhibited α‐amylase and α‐glucosidase, with AL having higher α‐amylase inhibitory properties (IC50 = 223.41 µg/mL) than SM (IC50 = 293.90 µg/mL). Also, the extracts inhibited both ...
International Journal of Impotence Research, Published online: 29 June 2017; doi:10.1038/ijir.2017.25
Conclusion Erectile dysfunction is common in diabetic men, but the diagnosis of a neurogenic origin is challenging. This study showed that ESC measurement using Sudoscan® is feasible and more sensitive than SSR recordings to show penile sympathetic innervation impairment. This new test should be further studied to better define its diagnostic accuracy and clinical correlates.