Sevoflurane Promotes Regeneration of the Endothelial Glycocalyx by Upregulating Sialyltransferase
During ischemia-reperfusion injury, the endothelial glycocalyx is damaged by oxidative stress-induced release of hydrogen peroxide, leading to decreased endothelium-dependent vasodilation. The regenerative effects of sevoflurane on the endothelial glycocalyx and endothelium-dependent vasodilation in oxidative stress remain unclear. Sialic acid, which is a component of the glycocalyx, plays a key role in antioxidant activity and is catalyzed by the sialyltransferase, ST6Gal-I. We hypothesized that ST6Gal-I is involved in the sevoflurane-induced promotion of endothelial glycocalyx restoration and endothelium-dependent vasodilation after oxidative stress.
Source: Journal of Surgical Research - Category: Surgery Authors: Satoshi Kazuma, Yasuyuki Tokinaga, Motonobu Kimizuka, Ryu Azumaguchi, Kohsuke Hamada, Michiaki Yamakage Tags: Vascular Source Type: research