Do We Have Clinical Equipoise (or Uncertainty) About How Much Protein to Provide to Critically Ill Patients?

Do We Have Clinical Equipoise (or Uncertainty) About How Much Protein to Provide to Critically Ill Patients?
Nutr Clin Pract. 2019 Jun 07;:
Authors: Patel JJ, Rice T, Compher C, Heyland DK
Abstract
The current recommendation for protein dose in critically ill patients is 1.2-2.0 g/kg/d. Despite this recommendation, there is significant variation in the amount of protein prescribed and delivered worldwide. We contend clinical equipoise, or a state of genuine uncertainty about 2 (dosing) strategies, exists because guideline-based recommendations for protein dose in critically ill patients are rooted in a weak evidentiary base, leaving the clinician with no good basis for choosing a lower or higher protein dose. We outline evidence for and against high protein dose and introduce a pragmatic, registry-based, multicenter, randomized controlled trial, known as EFFORT, which aims to resolve the high vs low protein dose controversy.
PMID: 31175689 [PubMed - as supplied by publisher]

Source: Nutrition in Clinical Practice - June 6, 2019 Category: Nutrition Authors: Patel JJ, Rice T, Compher C, Heyland DK Tags: Nutr Clin Pract Source Type: research