“Holidays” for osteoporosis drugs: A case-based approach

Publication date: Available online 8 June 2019Source: Case Reports in Women's HealthAuthor(s): Panagiotis Anagnostis, Stavroula A. Paschou, Eustathios Kenanidis, Irene Lambrinoudaki, Michael Potoupnis, Eleftherios Tsiridis, Dimitrios G. Goulis
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research

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ConclusionsOsteoarthritic deteriorations of subchondral bone induced by hip dysplasia spread throughout the whole joint, but exhibit region-dependent variations, with the weight-bearing region more seriously affected. Biomechanical stress might exert a pivotal impact on subchondral bone homeostasis in hip dysplasia.The translational potential of this articleThe histomorphometric findings in the project indicate an early intervention for the development of hip dysplasia in clinic.
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research
Authors: Thiele K, Hube R Abstract The patient's demands and expectations after total hip arthroplasty have increased significantly. In particular, the athletic function is the focus of the patient's interest, whereby not the basic sports ability is inquired, but also the achievable sports level. The benefits of increased activity with a reduction in cardiovascular mortality and the minimization of osteoporosis risk are contrasted by amplified wear followed by prosthesis loosening. Activities are categorized in low-, intermediate- and high-impact kind of sport. Patient-based influencing factors such as physical con...
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
For Dr. Patrick Dowling, volunteering at the 2019Care Harbor free clinic for people who are uninsured or who lack access to health care is a sharp break from his norm of treating people at UCLA Medical Center, Santa Monica.This atypical setting on the front lines of health care for the most vulnerable, sometimes results in unorthodox treatments.Dowling and other care givers at the annual clinic held at The Reef in downtown Los Angeles noticed that although the 60-year-old man they were treating said he had given himself insulin prior to his arrival at the clinic, his blood sugar level had fallen too low.Typically, physicia...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
In this study, we aimed to investigate the risk factors contributing to secondary vertebral compression fractures (SVCF) in patients undergoing percutaneous vertebroplasty (PVP) or kyphoplasty (PKP) due to osteoporotic vertebral compression fracture (OVCF). MATERIAL AND METHODS Between January 2010 and December 2017, 650 patients with regular follow-up were identified and retrospectively analyzed in this study. Of these patients, 410 patients underwent PVP and 240 patients underwent PKP surgery. Patients were followed for 24 months on average, ranging from 6 months to 36 months follow-up. Possible risk factors screened for...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 19 November 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Juliet Compston
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
(Cornell University) Cornell researchers have made a new discovery about how seemingly minor aspects of the internal structure of bone can be strengthened to withstand repeated wear and tear, a finding that could help treat patients suffering from osteoporosis. It could also lead to the creation of more durable, lightweight materials for the aerospace industry.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionSince TBS and SQ1 –SQ3 fractures were not associated, they may act as independent risk factors, justifying the use of both in post-fracture risk assessment.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
ConclusionsUsing real-world data, our model indicated that widespread use of zoledronate was of both clinical and economic benefit among Chinese postmenopausal women. Using a FRAX-based intervention threshold of 7% with zoledronate should permit cost-effective access to therapy to patients and contribute to reducing the disease burden of osteoporosis in Mainland China.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
ConclusionOlder women with mild-moderate reduction of kidney function are at increased risk of fractures, but not those with the worst function. Our findings furthermore confirm the value of osteoporosis assessment and it is possible that in this age group, age-related decline of kidney function has limited contribution compared with BMD.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewFractures of osteoporotic bone in elderly individuals need special attention. This manuscript reviews the current strategies to provide sufficient fracture fixation stability with a particular focus on fractures that frequently occur in elderly individuals with osteoporosis and require full load-bearing capacity, i.e., pelvis, hip, ankle, and peri-implant fractures.Recent FindingsElderly individuals benefit immensely from immediate mobilization after fracture and thus require stable fracture fixation that allows immediate post-operative weight-bearing. However, osteoporotic bone has decreased holdi...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
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