Dosimetric and preparation procedures for irradiating biological models with pulsed electron beam at ultra-high dose-rate

The progress of radiotherapy (RT) over the last few decades was mostly obtained in improving the spatial and dosimetric accuracy of the delivered dose to the patient [1,2]. Lately, a RT technique called FLASH-RT has emerged and questioned some established RT concepts regarding the effects of radiation on healthy tissue. Indeed, preclinical studies in FLASH-RT have shown that irradiations with an ultra-high dose-rate increase the differential response between normal tissues and tumors [3 –6]. In order to reveal differential biological effects, radiobiological studies required a traceable, accurate and repeatable dose delivery.

Source: Radiotherapy and Oncology - June 3, 2019 Category: Radiology Authors: Patrik Gon çalves Jorge, Maud Jaccard, Kristoffer Petersson, Maude Gondré, Maria Teresa Durán, Laurent Desorgher, Jean-François Germond, Philippe Liger, Marie-Catherine Vozenin, Jean Bourhis, François Bochud, Raphaël Moeckli, Claude Bailat Tags: Original Article Source Type: research