Signal Transducer and Activator of Transcription 3 in Keratinocytes Regulates Histaminergic Itch but Not Nonhistaminergic Itch.

Signal Transducer and Activator of Transcription 3 in Keratinocytes Regulates Histaminergic Itch but Not Nonhistaminergic Itch. Acta Derm Venereol. 2019 May 29;: Authors: Hashimoto T, Sakai K, Yosipovitch G, Akiyama T PMID: 31141156 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
POLLEN COUNTS have been forecast as high across the UK today and it could spell trouble for hay fever sufferers. Here are five tips sufferers need to remember to keep itchy eyes and sneezing at bay.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
POLLEN COUNTS have been forecast as high across the UK today and it could spell trouble for hay fever sufferers. Here are five tips sufferers need to remember to keep itchy eyes and sneezing at bay.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Chronic nodular prurigo is a skin condition characterized by intensely pruritic nodules, attributed to a repetitive itch-scratch cycle, and associated with multiple underlying conditions. Using a diagnostic algorithm, clinicians can make an accurate and timely diagnosis, and determine the optimal treatment strategy.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
(NIH/National Center for Advancing Translational Sciences (NCATS)) While scientists have some clues to the causes of troubling chronic itch, effective therapies have been elusive. Now, by sorting through more than 86,000 compounds at the same time, National Center for Advancing Translational Sciences researchers and their colleagues report a new strategy that may eventually help alleviate chronic itch. They've shown that blocking a receptor, or docking station, found on the surface of both mouse and human spinal cord neurons could be key.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Updated Date: Jul 11, 2019 EST
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Most people associate itchy skin with a rash, but many factors can cause itchy skin without creating a visible rash or skin changes. In this article, we discuss the possible causes and treatments of itching without a rash.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Dermatology Source Type: news
There is a major clinical need for new therapies for the treatment of chronic itch. Many of the molecular components involved in itch neurotransmission are known, including the neuropeptide NPPB, a transmitter required for normal itch responses to multiple pruritogens in mice. Here, we investigated the potential for a novel strategy for the treatment of itch that involves the inhibition of the NPPB receptor NPR1 (natriuretic peptide receptor 1). Because there are no available effective human NPR1 (hNPR1) antagonists, we performed a high-throughput cell-based screen and identified 15 small-molecule hNPR1 inhibitors. Using i...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
PMID: 31290556 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
This study compared patients with chronic pruritus (n = 79) of different origins (atopic dermatitis, chronic pruritus on non-lesional skin, chronic prurigo) and healthy controls (HC, n = 54) with regard to itch intensity and qualities of sensory symptoms after selective peripheral nerve fibre activation by electrical stimulation at 5 Hz (surrogate for C-fibre function) and 2,000 Hz (surrogate for Aβ-fibre function) using a Neurometer®. Electrically-induced itch was more intense in patients with chronic pruritus than in HC, but patients with chronic pruritus did not report "itch&quo...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
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