Fracture Risk Tool Useful for Women on Aromatase Inhibitors

Findings question considering aromatase inhibitors a'secondary cause of osteoporosis '
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Endocrinology, Gynecology, Oncology, Orthopedics, Pharmacy, Rheumatology, Journal, Source Type: news

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In conclusion, these genes play important roles in OP, which improves our understanding of pathogenesis of OP. PMID: 31217865 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Abstract The skeleton is one of the major retention sites for internally deposited actinides. Thus, an accurate estimation of the total skeleton content of these elements is important for biokinetic modeling and internal radiation dose assessment. Data from 18 whole-body donations to the US Transuranium and Uranium Registries with known plutonium intakes were used to develop a simple and reliable method for estimation of plutonium and Am activity in the total skeleton from single-bone analysis. A coefficient of deposition Kdep, defined as the ratio of actinide content in the patella to that in the skeleton, was ca...
Source: Health Physics - Category: Physics Authors: Tags: Health Phys Source Type: research
ConclusionsThe preventive intervention of a specialized unit at the start of AI treatment in breast cancer survivors allows the identification of patients with high fracture risk and may contribute to preventing bone events in these patients.ResumenObjetivoEvaluar el impacto de la intervención preventiva de una unidad de osteoporosis en supervivientes de cáncer de mama que inician un tratamiento con inhibidores de la aromatasa (IA).Material y métodosEstudio retrospectivo en mujeres posmenopáusicas con cáncer de mama precoz que iniciaron un tratamiento con IA tras la cirugía y/o qui...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
Publication date: July–August 2019Source: Reumatología Clínica (English Edition), Volume 15, Issue 4Author(s): Jorge Morales Torres
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
This study shows that Flexicurve can estimate radiographic vertebral centroid angles with less error than Cobb angles but that its accuracy would be inadequate for most clinical purposes.IntroductionThe Flexicurve ruler provides a non-radiological method of measuring thoracic kyphosis (TK) that has moderately strong correlations with the gold-standard radiographic Cobb angle method, while consistently underestimating the TK angle. Cobb angles can include measurement errors that may contribute to poor agreement, particularly in older populations. The vertebral centroid angle could be a better radiographic reference method f...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewIn perilacunar/canalicular remodeling (PLR), osteocytes dynamically resorb, and then replace, the organic and mineral components of the pericellular extracellular matrix. Given the enormous surface area of the osteocyte lacuna-canalicular network (LCN), PLR is important for maintaining homeostasis of the skeleton. The goal of this review is to examine the motivations and critical considerations for the analysis of PLR, in both in vitro and in vivo systems.Recent FindingsMorphological approaches alone are insufficient to elucidate the complex mechanisms regulating PLR in the healthy skeleton and in ...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
We present five unusual cases of insufficiency fractures occurring at the posterior non-weight-bearing zone of condyles. After investigating commonalities between these patients, we discovered that all of these patients performed the daily practice of prayer rituals that include high knee flexion.
Source: Clinical Imaging - Category: Radiology Authors: Tags: Musculoskeletal and Emergency Imaging Source Type: research
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Stefania R. Cicco, Danilo Vona, Gabriella Leone, Elvira De Giglio, Maria A. Bonifacio, Stefania Cometa, Saverio Fiore, Fabio Palumbo, Roberta Ragni, Gianluca M. FarinolaAbstractBisphosphonates are a class of drugs widely used in the clinical treatment of disorders of bone metabolism, such as osteoporosis, fibrous dysplasia, myeloma and bone metastases. Because of the negative side effects caused by oral administration of bisphosphonates, various silica mesoporous materials have been investigated for a confined and controlled r...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: 5 November 2019Source: Journal of Molecular Structure, Volume 1195Author(s): Jiaolong Wang, Wei Peng, Xinyu Li, Wenxiang Fan, Daneng Wei, Bo Wu, Linhong Fan, Chunjie Wu, Liang LiAbstractCathepsin K (CK) is the only cathepsin showing high expression in osteoclasts. CK is considered to be a drug target in treatment of osteoporosis, rheumatoid arthritis and osteoarthritis. Comprehensive application of quantitative structure–activity relationships (QSAR), molecular docking and absorption, distribution, metabolism, excretion and toxicity (ADMET) prediction was conducted for designing and screening for po...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Condition:   Male Osteoporosis Interventions:   Drug: Teriparatide or human parathyroid hormone (PTH) 1-34;   Drug: Cinacalcet;   Drug: placebo tablet;   Dietary Supplement: Calcium citrate tablet;   Dietary Supplement: Vitamin D3 Sponsors:   VA Office of Research and Development;   University of California, San Francisco Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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