Immune response pattern varies with the natural history of chronic hepatitis B.

CONCLUSION: Our findings demonstrate the changes in immune response pattern during the natural history of HBV infection. Both NK and T cells are functionally impaired in the IT and IA phases. With the spontaneous clearance of HBeAg and hepatitis B surface antigen decline, NK cell cytokine production and HBV-specific T responses are partially restored in IC phase, and the ENEG phase is dominated by nonantigen-specific T cell responses.
PMID: 31086463 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - April 27, 2019 Category: Gastroenterology Authors: Wang WT, Zhao XQ, Li GP, Chen YZ, Wang L, Han MF, Li WN, Chen T, Chen G, Xu D, Ning Q, Zhao XP Tags: World J Gastroenterol Source Type: research