MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms.

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms.
Biochem Soc Trans. 2019 May 07;:
Authors: Gifford V, Itoh Y
Abstract
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety of cell types both in physiological and pathological conditions. It promotes cell migration by degrading extracellular matrix on the cell surface and creates a migration path, by modifying cell adhesion property by shedding cell adhesion molecules to increase cell motility, and by altering cellular metabolism. Thus, MT1-MMP is a multifunctional cell motility enhancer. In this review, we will discuss the current understanding of the proteolytic and non-proteolytic mechanism of MT1-MMP-dependent cell migration.
PMID: 31064864 [PubMed - as supplied by publisher]

Source: Biochemical Society Transactions - May 6, 2019 Category: Biochemistry Authors: Gifford V, Itoh Y Tags: Biochem Soc Trans Source Type: research