The effectiveness of high molecular weight hyaluronic acid for knee osteoarthritis in patients in the working age: a randomised controlled trial

High molecular weight (HMW) hyaluronic acid (HA) is a treatment option for knee osteoarthritis (OA). The efficacy of HMW-HA in knee OA is investigated extensively, but the effectiveness in patients in the work...
Source: BMC Musculoskeletal Disorders - Category: Orthopaedics Authors: Tags: Research article Source Type: research

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CONCLUSION: The results of the study confirm the success rates of ankle fusions in the majority of cases. Well defined limitations and residual symptoms can be named on the basis of the available data. PMID: 31820431 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
Publication date: Available online 10 December 2019Source: The Egyptian RheumatologistAuthor(s): Amany R. El-Najjar, Shimaa M. Abdelwhab, ahmad A. elsammakAbstractBackgroundPain in osteoarthritis (OA) primarily results from tissue damage but its' intensity does not essentially parallel the extent of joint destruction or presence of active inflammation, thus suggesting the likely involvement of a central component. The mid-anterior cingulate cortex (mACC) has an important role in pain perception, intensity and progression. In OA, low mACC γ-aminobutyric acid (GABA) was associated with high pain suggesting a role of pr...
Source: The Egyptian Rheumatologist - Category: Rheumatology Source Type: research
Condition:   Knee Osteoarthritis Interventions:   Device: Electromyographic Biofeedback;   Other: Quadriceps Isometric exercises Sponsor:   Riphah International University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Osteoarthritis, Knee;   Pain Intervention:   Drug: Test Article Sponsor:   Pure Green Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 10 December 2019Source: European Journal of RadiologyAuthor(s): SS Xu, N Berkovitz, O Li, G GarvinAbstractPurposeTo evaluate reduction in inappropriate knee MRI requests following implementation of a mandatory knee MRI appropriateness checklist.MethodsA retrospective review was performed at a single tertiary care centre. A knee MRI appropriateness checklist was developed based on the ACR Appropriateness Criteria and adherence from referring physicians was mandatory. Reports from 200 consecutive knee MRI studies one year prior to implementation were compared to 200 consecutive knee MRI stu...
Source: European Journal of Radiology - Category: Radiology Source Type: research
Publication date: Available online 10 December 2019Source: Journal of OrthopaedicsAuthor(s): Prabhudev Prasad Purudappa, Om Prakash Sharma, Jayadev Chandrasekharan, Prasanth Jayakumari Sudevan, Varatharaj Mounasamy, Senthil Nathan SambandamAbstractBackgroundVarious authors have shown that Cruciate Retaining (CR) Total Knee Arthroplasty (TKA) has better long-term survivorship compared to Posterior Stabilized (PS), however most arthroplasty surgeons tend to use PS knees in patients with severe deformity and stiffness. There is limited data correlating stiffness and CR versus PS design. The aim of our study was to assess the ...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
ConclusionThe results suggested that medial knee osteoarthritis can be treated successfully with HTO. The post-operative valgus angle should be between 3-13 degrees of valgus to achieve good long-term results.
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
ConclusionLarger differences in calculated correction angles between pre-operative radiographs standing with and without LWI predicted larger changes in JLCA after HTO. Whole-leg radiograph standing on LWI is a promising modality for correct pre-operative planning considering patient-specific changes in JLCA before vs. after HTO.Level of evidenceIV.
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
ConclusionsWhen combined with IACSI, GNB yields better analgesic effect and improves function in patients with knee OA compared to only IACSI.
Source: Musculoskeletal Surgery - Category: Orthopaedics Source Type: research
Publication date: Available online 9 December 2019Source: International Journal of PharmaceuticsAuthor(s): Sakshi Tomar, Sarbani Chakraborti, Akshita Jindal, Maninderjeet Kaur Grewal, Renu ChadhaAbstractThe effectiveness of Diacerein as an anti-osteoarthritis drug is limited due to its acutely poor aqueous solubility and bioavailability. The present study demonstrates cocrystallization as a successful technique to improve the biopharmaceutical parameters of diacerein. Three cocrystals of diacerein were prepared by an eco-friendly technique with three suitable coformers namely isonicotinamide, nicotinamide, and theophylline...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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