Rosacea: update on management and emerging therapies.

Rosacea: update on management and emerging therapies. Skin Therapy Lett. 2012 Dec;17(10):1-4 Authors: Fallen RS, Gooderham M Abstract Rosacea is a common chronic skin disorder that has significant impact on the self-esteem and quality of life of affected individuals. Currently understood as an inflammatory condition that occurs in the context of an altered innate immune response, the available topical and systemic therapies function as immunomodulators to restore cutaneous homeostasis. The goals of therapy include reduction of papules, pustules, erythema and physical discomfort with improvement in quality of life. Standard topical treatments include metronidazole and azelaic acid, although many other agents and regimens have been presented. Subantimicrobial/antiinflammatory dose oral doxycycline was US FDA approved in 2006 for the management of rosacea, but Health Canada clearance was only recently granted for this indication. Furthermore, renewed research interest has led to the development of other emerging therapies including topical ivermectin, brimonidine and oxymetazoline that hold promise for patients suffering from this condition. PMID: 23223767 [PubMed - in process]
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research

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Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity. The pilosebaceous unit is a site for production and metabolism of a number of steroid hormones, including stress and sex hormones. This is an overview of the important role that the cutaneous HPA-like-axis plays in the pathogenesis and treatment of inflammatory pilosebaceous disorders, including acne, rosacea, seborrheic dermatitis, and hidradenitis suppurativa.
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
Conclusions: RCM enables anti-inflammatory effect monitoring of topical ivermectin by determining mite presence. Quantifying exact mite number, and inflammatory and vascular characteristics is challenging due to device limitations. In its current form, RCM seems of limited value for noninvasive follow-up of rosacea in clinical practice. PMID: 32189533 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Abstract Rosacea is a chronic and relapsing inflammatory cutaneous disorder with highly variable prevalence worldwide that adversely affects the health of patients and their quality of life. However, the molecular characterization of each rosacea subtype is still unclear. Furthermore, little is known about the role of long noncoding RNAs (lncRNAs) in the pathogenesis or regulatory processes of this disorder. In the current study, we established lncRNA-mRNA coexpression networks for three rosacea subtypes (erythematotelangiectatic, papulopustular, and phymatous) and performed their functional enrichment analyses us...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Rosacea is a common, chronic inflammation of sebaceous gland-rich facial skin characterized by severe skin dryness, elevated pH, transepidermal water loss, and decreased hydration levels. Until now, there has been no thorough molecular analysis of permeability barrier alterations in the skin of rosacea patients. Thus, we aimed to investigate the barrier alterations in papulopustular rosacea (PPR) samples compared to healthy sebaceous gland-rich (SGR) skin, using RNASeq analysis (n=8). Pathway analyses by Cytoscape ClueGo revealed 15 significantly enriched pathways related to skin barrier formation.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Public health authorities are advising frequent hand washing and social distancing, especially in the absence of confirmatory testing for COVID-19. I don’t have any wisdom to add to these practices. Vaccines are in the works, as are anti-viral drugs—nothing to add here, either. But let me reiterate what we do in the Wheat Belly and Undoctored lifestyles. In general, we do not treat diseases; we correct the factors that allow disease to emerge in the first place—a big difference. Take rheumatoid arthritis, for example. In conventional healthcare, the joint pain and swelling of rheumatoid arthritis are...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open probiotic undoctored wheat belly Source Type: blogs
PMID: 32189331 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
This case series demonstrates how the use of photodynamic therapy, specifically via light-emitting diodes, can provide an effective, safe, and well-tolerated alternative treatment for acne rosacea.Journal of Medical Case Reports
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
AbstractPurpose of ReviewOngoing investigations of the human skin microbiome strongly suggest a connection to skin diseases and skin health. This review provides an overview of recent literature on the skin microbiome in relation to skin diseases, with a specific focus on common inflammatory skin conditions, such as atopic dermatitis, psoriasis, hidradenitis suppurativa, acne, and rosacea.Recent FindingsIn healthy subjects, the skin microbiome mediates fundamental processes involving the immune response and epidermal development and differentiation. Microbiome characteristics in inflammatory skin diseases differ depending ...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
ABSTRACT Purpose: To compare the impact of ocular changes between systemic treatment with doxycycline and low-dose oral isotretinoin in patients with moderate-to-severe papulopustular rosacea. Methods: Patients were randomized to receive either isotretinoin 0.3-0.4 mg/kg (group A) or doxycycline 100 mg/day (group B) for 16 weeks. Ocular symptoms were searched and evaluated, including best-corrected visual acuity (BCVA), Schirmer test, breakup time, rose bengal staining score, and meibomian gland dysfunction grading. The patients were retested at the end of treatment. Results: The present study included 39 patients (30 fema...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research
Conclusion This study supports the efficacy of PDL treatment for patients with rosacea. PDL could be more effective when combined with ivermectin 1% cream. PMID: 32141785 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
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