Metabolic disease: Weight loss herb targets GPCR

Nature Reviews Drug Discovery 13, 888 (2014). doi:10.1038/nrd4498 Author: Sarah Crunkhorn The African cactiform Hoodia gordonii exhibits anorexant properties, but the active components and molecular targets remain unclear. Here, a screen of 4,400 natural products identified Gordonoside F — a pregnane steroidal glycoside isolated from Hoodia gordonii — to activate GPR119, a GPCR highly
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research