Effect of NSAIDs on Bone Healing Rates: A Meta-analysis Effect of NSAIDs on Bone Healing Rates: A Meta-analysis

NSAIDs are effective pain relievers, but might their use lead to delayed bone fracture healing?Journal of the American Academy of Orthopaedic Surgeons
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Orthopaedics Journal Article Source Type: news

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Background: Many of those aging with HIV suffer from distal neuropathic pain (DNP) due to HIV-associated sensory neuropathy (HIV-SN). Prior studies have linked chronic pain conditions to a variant of the catechol-O-methyltransferase (COMT), Val158Met. This variant confers reduced enzymatic activity and results in higher synaptic dopamine levels. Here we examined the role of Val158Met as a predictor of DNP in HIV-SN. Methods: In 1044 HIV-infected individuals enrolled in CNS HIV Antiretroviral Therapy Effects Research, an observational study across six US institutions, we characterized the relationship between Val158Met...
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
ConclusionsThis study indicates that L-OHP treatment specifically upregulated PGE2 secretion by vascular endothelial cells, which may contribute to vascular pain, and that NSAIDs can be used to inhibit PGE2 release and attenuate L-OHP-induced hyperalgesia.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
This study aimed to evaluate the effect of preoperative carbohydrate oral (CHO) loading on the postoperative metabolic and inflammatory response, perioperative discomfort and surgical clinical outcomes in open colorectal surgery compared with a conventional fasting protocol.MethodsFifty patients were randomly allocated to either the intervention group (CHO), to receive preoperative oral carbohydrate supplementation, or the control group (FAST), to undergo preoperative fasting. Insulin resistance, insulin sensitivity, the Glasgow Prognostic Score (GPS) and IL-6 levels were analysed at 06  h on the day of surgery (T1), ...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
ConclusionsOur scoping review found the majority of published articles described chiropractic services in the active duty military in the US setting. Recent RCTs suggest a benefit of including chiropractic care to usual medical care in managing back pain in active duty military. Yet despite reported benefits in Australia, Canada, and the US, there is a need for further qualitative, descriptive, and clinical trial data worldwide to inform the role of chiropractic services in active duty military.
Source: Chiropractic and Manual Therapies - Category: Complementary Medicine Source Type: research
AbstractOsteoarthritis (OA) is a common cause of chronic pain and disability. Regenerative therapies using mesenchymal stem cells (MSCs) provide an option for OA treatment as it could potentially regenerate the damaged cartilage. Bone marrow, adipose tissue and synovium are common MSC sources. The aim is to compare the therapeutic effect of MSCs from bone marrow, adipose tissue and synovium; combining its differentiation potential and accessibility, to decide the optimal source of MSCs for the treatment of knee OA. A comparison of preclinical and clinical studies using MSCs has been made with regard to treatment outcomes, ...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
Dear Candid Caregiver: As far back as I can remember my grandmother has had a dog. For the last 10 years, this dog has been Tippy, a small, male, mixed-breed that has been an ideal companion. The problem is that Grandma is getting less able to care for herself — let alone Tippy — and she is going to need to move to an assisted living facility (ALF). I’ve checked around, and while some local ALFs will let people bring their cats... Read the full column on HealthCentral to learn more about the pain of leaving behind a pet: Carol Bradley Bursack is the Candid Caregiver MedicareFAQ – Medicare Resou...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Publication date: Available online 13 July 2019Source: Journal of Clinical Orthopaedics and TraumaAuthor(s): Nipith Charoenngam, Arash Shirvani, Michael F. HolickAbstractVitamin D plays an essential role in regulating calcium and phosphate metabolism and maintaining a healthy mineralized skeleton. Humans obtain vitamin D from sunlight exposure, dietary foods and supplements. There are two forms of vitamin D: vitamin D3 and vitamin D2. Vitamin D3 is synthesized endogenously in the skin and found naturally in oily fish and cod liver oil. Vitamin D2 is synthesized from ergosterol and found in yeast and mushrooms. Once vitamin...
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
CONCLUSION: This pilot study, conducted in India, revealed valid positive results for a promising new technology. The manual preparation of platelet-rich plasma could be automated in the future to allow a larger sample size. PMID: 31296273 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
This study is registered with ClinicalTrials.gov, number NCT03461757, and is closed to accrual.FindingsBetween Feb 27 and Aug 28, 2018, 1811 participants were recruited and assessed for eligibility. 1466 participants were randomly assigned to the rimegepant (n=732) or placebo (n=734) groups, of whom 1375 received treatment with rimegepant (n=682) or placebo (n=693), and 1351 were evaluated for efficacy (rimegepant n=669, placebo n=682). At 2 h postdose, rimegepant orally disintegrating tablet was superior to placebo for freedom from pain (21% vs 11%, p
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 13 July 2019Source: Annals of Medicine and SurgeryAuthor(s): Shah Fahad, Pervaiz Hashmi, Muhammed Zohaib Nawaz Khan, Talal AqueelAbstractBackgroundThe standard treatment of displaced femoral neck fracture is arthroplasty. THA is reportedly superior to BHA in terms of hip pain, function and reoperation rate. On the other hand THA has a higher rate of dislocation. Total hip replacement with dual mobility cup increases the range of motion and reduces the chances of dislocation. The aim of this study is to compare the functional outcome, rate of dislocation, complications and mortality betwee...
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
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