Ask D'Mine: On Easter, Beta Cell Resurrection with Diabetes?

Our weekly diabetes advice column explores whether the dead insulin-producing beta cells in people with diabetes can ever be brought back to life.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs

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CONCLUSIONS: This study indicates a relationship between antipsychotic adherence and improved diabetes outcomes among individuals with schizophrenia. Engagement in mental health treatment may be a critical path toward improving health disparities for individuals with schizophrenia. Individuals with very low to no engagement were a particularly vulnerable group, and the exclusion of persons with less than two prescriptions from research and quality measures should be revisited. PMID: 31744428 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
CONCLUSIONS: Diabetes quality of care may be contingent on receipt of medically focused primary care, psychiatric stability, and receipt of specialist psychiatric care. PMID: 31744427 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP‑sensitive potassium channel channels in rats. Mol Med Rep. 2019 Nov 05;: Authors: Jiao Y, Yu Y, Li B, Gu X, Xie K, Wang G, Yu Y Abstract It has previously been demonstrated that hyperglycemia‑induced oxidative stress and inflammation are closely associated with the development of diabetic complications, including diabetic neuropathy. Additionally, mitochondrial ATP‑sensitive potassium (Mito‑K‑ATP) channels play a homeostatic role on blood glucose regulation ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Retinal proteomic evaluation of rats following streptozotocin‑injection using shotgun proteomics. Mol Med Rep. 2019 Nov 06;: Authors: Otake H, Yamamoto T, Deguchi S, Taga A, Nagai N Abstract It is important to elucidate how retinal stimulation leads to retinal protection and dysfunction. The current study aimed to identify factors that are up‑ and downregulated in the retinas of streptozotocin (STZ)‑induced diabetic rats with acute retinal dysfunction. Retinal function was measured and changes in protein expressions were determined using electroretinograms (ERGs) and liquid chromatography/mass sp...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
In this study, the focus was on the impact of dioscin on the function of DCs. Immature DCs were cultured with: 5.5 mM glucose medium (control group); 30 mM glucose medium (HG group); HG + 10 mM dioscin; HG + 20 mM dioscin; HG + 30 mM dioscin; and HG + 40 mM dioscin. For subsequent experiments, 30 mM dioscin was used as the experimental concentration. Dichlorodihydrofluorescein fluorescence was used to measure the intracellular production of reactive oxygen species (ROS) in DCs. The expression levels of the scavenger receptors, including class A scavenger receptors (SR‑A), CD36 and lecti...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
CONCLUSIONS: In this large population of patients who had R-ZES implanted, 5-year clinical outcomes were similar whether or not the stents were implanted in total occlusions. PMID: 31746760 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Publication date: 15 December 2019Source: Life Sciences, Volume 239Author(s): Asmaa S.A. Hammad, Al-Shaimaa F. Ahmed, Gehan H. Heeba, Ashraf TayeAbstractEndothelial dysfunction is a common complication of diabetes that mainly stems from increased reactive oxygen species, which makes antioxidants of great benefit. Resveratrol (RSV) is an antioxidant that shows protective effects in a variety of disease models where the ameliorative effect appears to be mediated, in part, via heme oxygenase-1 (HO-1) induction. However, the pathophysiological relevance of HO-1 in the ameliorative response of RSV in endothelial dysfunction is ...
Source: Life Sciences - Category: Biology Source Type: research
CONCLUSIONS: Taken together, these data demonstrate that CRISPLD2 is a circulating adipokine that may regulate adipocyte remodeling during weight loss. PMID: 31746554 [PubMed - in process]
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
This study offers some evidence for DSME providers to explore vouchers as one approach to increase program completion.
Source: Journal of Public Health Management and Practice - Category: Health Management Tags: Research Reports: Research Brief Report Source Type: research
Telomeres are repetitive nucleotides sequences localized to the ends of each individual chromosome. They are replicated during each cellular division, but with each cell cycle they become progressively shorter. The problem is short telomeres are associated with dysregulation of cellular events such as senescence or cell death. The shortening process is accelerated by exposure to stress, smoking, obesity, lack of exercise, and poor diet. Many refer to this process as one of our “biological clocks.” In long-term studies, shortened telomeres are associated with adverse health outcomes including atherosclerosis, st...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
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