014 Psoriatic regulatory T cells are impaired in their suppressive activity and respond differently to IL-33

Interleukin 33 (IL-33), initially described as an alarmin released by cells following cell damage, can also act immunosuppressive by inducing regulatory T cells (Treg). Disruption of the skin barrier by tape stripping in mice released IL-33 which induced Treg. Accordingly, contact hypersensitivity (CHS) was suppressed upon barrier disruption. Furthermore, blockade of IL-33 enhanced CHS, whereas injection of IL-33 suppressed CHS via induction of Treg. IL-33 is enhanced in the skin and serum of psoriatic patients.

Source: Journal of Investigative Dermatology - April 19, 2019 Category: Dermatology Authors: T. Schwarz, A. Schwarz Tags: Adaptive and Auto-Immunity Source Type: research