016 Brunsting-Perry pemphigoid after remission of previous bullous pemphigoid related to epitope spreading from BP180 to BP230

Brunsting –Perry pemphigoid is a localized form of cicatricial pemphigoid. Here, we report a case of Brunsting–Perry pemphigoid after remission of previous bullous pemphigoid. A 63-year-old Chinese male presented to our department with a three-month history of pruritic lesions in August 2013. Tense vesicl es and bullae appeared on his hands, upper limbs and trunk. The skin biopsy showed subepidermal bulla with eosinophil infiltrations in upper dermis. The enzyme-linked immunosorbent assay (ELISA) for IgG antibodies against the BP180 NC16A domain was 90.44 and for the BP230 was 33.75.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive and Auto-Immunity Source Type: research