FDA bans sales of transvaginal mesh amid safety concerns
Manufacturers of surgical mesh products must stop selling and distributing their products in the United States immediately, the US Food and Drug Administration ordered Tuesday.
The Diabetes Empowerment Summit is a free virtual conference taking place May 1-5, 2019, that offers many mental health resources for coping with diabetes.
Background/Aims: Peptide receptor radionuclide therapy (PRRT) is becoming clinical routine for management of Neuroendocrine Tumours. The number of PRRT cycles are correlated with treatment effect but theoretically limited by off-target radiation damage to kidneys and bone marrow. New imaging biomarkers for assessment of PRRT tissue damage would enable evaluation of novel renal and bone marrow protective agents, as well as personalized PRRT treatment regiments. Methods: Mice treated with [177Lu]Lu-DOTA-TATE PRRT or vehicle were examined at baseline and following treatment with [18F]FLT PET and [99mTc]Tc-Mag3 SPECT to asses...
These authors from Hungary highlight that no studies to date have employed the EuroQol EQ-5D questionnaire to assess health-related quality of life (HRQoL) in patients with pemphigus. Their aim with this study was to evaluate the HRQoL of patients with pemphigus by the EQ-5D and to analyse the convergent and known-groups validity of the EQ-5D in this patient population. To do this they carried out a multicentre cross-sectional study between 2014 and 2017. Their outcome measures included the five-level EQ-5D, Dermatology Life Quality Index, Autoimmune Bullous Skin Disorder Intensity Score and an average pain-intensity visua...
Editorial note: Welcome to the Journal of Investigative Dermatology (JID) Cells to Surgery Quiz. In this monthly online-only quiz, the first question relates to the clinical image above, while additional questions concern the findings reported in a JID article by Olsen et al. (https://dx.doi.org/10.1016/j.jid.2018.09.022) that provides new information about that disease entity.
A key factor that determines the applicability of trial evidence to clinical guidelines is the choice of outcomes. In an evaluation of 10 Cochrane Skin systematic reviews and 220 clinical trials, Schmitt and colleagues found a low degree of agreement between trial and review outcomes. A significant number of outcomes sought by reviews were not assessed in dermatological trials, potentially introducing weakness in systematic review c onclusions. Better concordance was observed between the trials and reviews for outcome domains, fortuitously suggesting that trialists and reviewers typically consider similar aspects of disease.
Observational evidence indicates a relationship between increased body mass index (BMI) and psoriasis, but the direction of causality remains unclear. Using mendelian randomization, which randomly allocates individuals to groups based on genotype, of more than 750,000 individuals from large population-based and genome-wide association studies, Budu-Aggrey and colleagues demonstrated that higher BMI causally increases the odds of psoriasis occurrence. This increase is likely to be clinically significant because a 1 kg/m2 increase in BMI increases the odds of psoriasis by 9%.
Editorial note: Welcome to the Journal of Investigative Dermatology (JID) SnapshotDx Quiz. In this monthly online-only quiz, the first question ( “What is your diagnosis?”) relates to the clinical image above, while additional questions concern the findings reported in a JID article by Zaalberg et al. (https://dx.doi.org/10.1016/j.jid.2018.03.1522).