'Damn it was good': N.S. woman made most of life after cancer diagnosis

A 35-year-old Nova Scotia woman who died of cancer last week summed up her life in her self-written obituary by saying '35 years may not seem long, but damn it was good!'
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Nova Scotia Source Type: news

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In conclusion, these data indicate that KIF23 is a potential therapeutic target for gastric cancer treatment. PMID: 31007778 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Publication date: Available online 22 April 2019Source: Life Sciences in Space ResearchAuthor(s): L. Walsh, U. Schneider, A. Fogtman, C. Kausch, S. McKenna-Lawlor, L. Narici, J. Ngo-Anh, G. Reitz, L. Sabatier, G. Santin, L. Sihver, U. Straube, U. Weber, M. DuranteAbstractThe European Space Agency (ESA) is currently expanding its efforts in identifying requirements and promoting research towards optimizing radiation protection of astronauts. Space agencies use common limits for tissue (deterministic) effects on the International Space Station. However, the agencies have in place different career radiation exposure limits (f...
Source: Life Sciences in Space Research - Category: Biology Source Type: research
Publication date: Available online 23 April 2019Source: Life SciencesAuthor(s): Muzammal Hussain, Dickson Adah, Muqddas Tariq, Yongzhi Lu, Jiancun Zhang, Jinsong LiuAbstractThe tumor microenvironment comprises stromal and tumor cells which interact with each other through complex cross-talks that are mediated by a variety of growth factors, cytokines, and chemokines. The chemokine ligand 13 (CXCL13) and its chemokine receptor 5 (CXCR5) are among the key chemotactic factors which play crucial roles in deriving cancer cell biology. CXCL13/CXCR5 signaling axis makes pivotal contributions to the development and progression of ...
Source: Life Sciences - Category: Biology Source Type: research
In this study, the antifungal activity of base analogues, 5-flucytosine (5-FC) and 5-fluorouracil (5-FU), was tested against planktonic cells as well as against mature biofilm.MethodsTests were performed according the EUCAST methodology. Antibiofilm effectiveness of tested drugs was determined by the crystal violet staining method. The cytotoxicity assays was performed according to the ISO 10993-5 norm.Results5-FC and 5-FU were effective against fifteen fluconazole resistant Candida glabrata strains with an average minimal inhibitory concentration (MIC) of 0.152 mg/L and 0.39 mg/L, respectively. Folinic acid (fol...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Publication date: Available online 22 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Shengtao Wang, Jingtao Li, Zhou Ye, Jieling Li, Anhe Wang, Jing Hu, Shuo Bai, Jian YinAbstractHerein, an amphipathic polymeric photosensitizer, designated as PEGylated distyryl boron dipyrromethenes with real-time tracing property, is synthesized as a kind of multifunctional carrier to load drugs for combined photodynamic-chemo therapy. The hydrophilic PEG side chains on the carriers prolong its blood circulation time and the self-assembly capacity of PEGylated distyryl boron dipyrromethenes ef...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 22 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Srinivasan Ayyanaar, Mookkandi Palsamy Kesavan, Gandhi Sivaraman, Balaji Maddiboyina, Jamespandi Annaraj, Jegathalaprathaban Rajesh, Gurusamy RajagopalAbstractPoly(D, L-lactide-co-glycolic acid) (PLGA) based magnetic microspheres (MMS) hold immense potential for reaching the target of controlled and specific drug delivery site with low toxicity. Herein, we have synthesized the biodegradable PLGA microspheres (MS) containing magnetic iron oxide nanoparticles (MIONPs) by the emulsion solvent evap...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 22 April 2019Source: Chemical Engineering JournalAuthor(s): Yingying Zhang, Lu Zhang, Xiaowen Lin, Lingjie Ke, Bifei Li, Liang Xu, Tingting Lv, Ziying Li, Haijun Chen, Yu GaoAbstractThe clinical outcome of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors is limited by the ambiguous molecular subtypes of non-small cell lung cancer (NSCLC) patients and the emergence of drug-resistance. Here, a nanotheranostic agent ECMI, which is indocyanine green (ICG)-loaded mesoporous silica nanoparticles lidded with ZnO QDs and wrapped with erlotinib-modified chitosan, was developed fo...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8NJ06517A, PaperFaria Sultana, Mohd Aslam Saifi, Sd Riyaz, Geeta Sai Mani, Siddiq Pasha Shaik, Egharevba godshelp osas, Chandraiah Godugu, syeda Shahjahan, Ahmed Kamal Abstract: A series of 2-anilinopyridyl linked benzothiazole-hydrazone conjugates (5a-aa) were designed synthesized and evaluated for their in vitro cytotoxic potency against a panel of cancer cell lines like mouse skin... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Lab Chip, 2019, Accepted Manuscript DOI: 10.1039/C9LC00210C, PaperWujun Zhao, Yang Liu, Brittany D. Jenkins, Rui Cheng, Bryana N. Harris, Weizhong Zhang, Jin Xie, Jonathan R. Murrow, Jamie Hodgson, Mary Egan, Ana Bankey, Petros G. Nikolinakos, Haythem Y. Ali, Kristina Meichner, Lisa A. Newman, Melissa B. Davis, Leidong Mao Isolation of circulating tumor cells (CTCs) from blood provides a minimally-invasive alternative into the basic understanding, diagnosis and prognosis of metastatic cancers. The roles and clinical values of CTCs are... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC01454C, CommunicationMingming Luan, Mingwan Shi, Wei Pan, Na Li, Bo Tang A novel Au-Se nanoprobe with remarkable anti-interference ability for glutathione was developed to real-time in situ monitor the upstream and downstream regulatory relationship between uPA and MMP-9 proteins in the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
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